Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.44 |
| ▸ | CYP4F2 | P78329 | 2/20 | 0.44 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3929847 | 0.83 | HAO1 (0.50) | LMNAHAO1CYP1A2CYP2C9 | |
| SCHEMBL1637624 | 0.83 | ACACB (0.46) | LMNAALDH1A1L3MBTL1TSHRHAO1 | |
| SCHEMBL10411912 | 0.82 | ALDH1A1 (0.52) | ALDH1A1CYP3A4MAPK1LOXL2TSHR | |
| SCHEMBL16719850 | 0.82 | GABRA1 (0.53) | ALDH1A1CYP3A4MAPK1LOXL2TSHR | |
| SCHEMBL3121665 | 0.81 | GRM5 (0.50) | LMNATSHRHAO1 | |
| SCHEMBL22031725 | 0.81 | LMNA (0.59) | LMNAALDH1A1LOXL2L3MBTL1TSHR | |
| SCHEMBL4672150 | 0.81 | ALDH1A1 (0.51) | ALDH1A1CYP3A4MAPK1LOXL2TSHR | |
| SCHEMBL1926585 | 0.81 | TSHR (0.60) | LMNAALDH1A1CYP3A4MAPK1LOXL2 | |
| SCHEMBL1637026 | 0.80 | L3MBTL1 (0.52) | LMNAALDH1A1CYP3A4MAPK1L3MBTL1 | |
| SCHEMBL16720308 | 0.80 | KDM4E (0.55) | ALDH1A1CYP3A4MAPK1LOXL2L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1831198-B1 | PYRIDINE CARBOXAMIDE DERIVATIVES FOR USE AS ANTICANCER AGENTS | ASTRAZENECA AB (SE) | 2009-04-08 | — | — | EP | disclosed |