Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | PGK1 | P00558 | 1/20 | 0.33 |
| ▸ | PGK2 | P07205 | 1/20 | 0.33 |
| ▸ | CTSS | P25774 | 1/20 | 0.33 |
| ▸ | CTSK | P43235 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | PDK1 | Q15118 | 2/20 | 0.31 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.31 |
| ▸ | PDK3 | Q15120 | 2/20 | 0.31 |
| ▸ | PDK4 | Q16654 | 2/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | HMGCR | P04035 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1562256 | 1.00 | ALDH1A1 (0.35) | ALDH1A1TSHRPGK1PGK2CTSS | |
| SCHEMBL1562258 | 1.00 | ALDH1A1 (0.35) | ALDH1A1TSHRPGK1PGK2CTSS | |
| SCHEMBL3939178 | 0.84 | PSEN1 (0.34) | ALDH1A1TSHRPGK1PGK2PDK1 | |
| SCHEMBL1562887 | 0.84 | PSEN1 (0.34) | ALDH1A1TSHRPGK1PGK2PDK1 | |
| SCHEMBL15271680 | 0.82 | PGK1 (0.38) | ALDH1A1PGK1PGK2CTSSCTSK | |
| SCHEMBL1562473 | 0.82 | PGK1 (0.32) | ALDH1A1PGK1PGK2MEN1KMT2A | |
| SCHEMBL1562477 | 0.82 | PGK1 (0.32) | ALDH1A1PGK1PGK2MEN1KMT2A | |
| SCHEMBL1562086 | 0.80 | ALDH1A1 (0.38) | ALDH1A1TSHRPGK1PGK2MEN1 | |
| SCHEMBL3934762 | 0.80 | ALDH1A1 (0.38) | ALDH1A1TSHRPGK1PGK2MEN1 | |
| SCHEMBL1562308 | 0.80 | MMP8 (0.39) | ALDH1A1MEN1KMT2AKDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2018368-B1 | MALONAMIDE DERIVATIVES AS GAMMA SECRETASE INHIBITORS | HOFFMANN LA ROCHE (CH) | 2012-12-05 | — | — | EP | disclosed |
| EP-2109604-A1 | 6-OXO-6,7-DIHYDRO-5H-DIBENZO[B,D]AZEPIN-7-YL DERIVATIVES | F. Hoffmann-Roche AG (CH) | 2009-10-21 | — | — | EP | disclosed |
| US-7544679-B2 | 6-oxo-6,7-dihydro-5h-dibenzo[b,d]azepin-7-yl derivatives | HOFFMAN-LA ROCHE INC. (US) | 2009-06-09 | — | — | US | disclosed |
| US-7425551-B2 | Malonamide derivatives | HOFFMANN-LA ROCHE INC. (US) | 2008-09-16 | — | — | US | disclosed |
| WO-2008092786-A1 | 6-OXO-6,7-DIHYDRO-5H-DIBENZO[B,D]AZEPIN-7-YL DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2008-08-07 | — | — | WO | disclosed |
| US-20080188463-A1 | 6-OXO-6,7-DIHYDRO-5H-DIBENZO[B,D]AZEPIN-7-YL DERIVATIVES | HOFFMANN-LA ROCHE, INC. | 2008-08-07 | — | — | US | disclosed |
| US-20070225273-A1 | Malonamide derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 2007-09-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070225273-A1 | Malonamide derivatives | ACE, APP, NAAA | ALDH1A1 92/4885TSHR 1918/4885PGK1 3002/4885 |
| US-20080188463-A1 | 6-OXO-6,7-DIHYDRO-5H-DIBENZO[B,D]AZEPIN-7-YL DERIVATIVES | BACE1, BACE2, APH1B | ALDH1A1 795/4885TSHR 4173/4885PGK1 3242/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.