Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.45 |
| ▸ | MAOA | P21397 | 1/20 | 0.45 |
| ▸ | MAOB | P27338 | 1/20 | 0.45 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.45 |
| ▸ | FER | P16591 | 1/20 | 0.45 |
| ▸ | LTK | P29376 | 1/20 | 0.45 |
| ▸ | CDK8 | P49336 | 1/20 | 0.45 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.45 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.45 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 6/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | IDO1 | P14902 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL302509 | 0.83 | MAOA (0.37) | LRRK2MAOAMAOBPDGFRAFER | |
| SCHEMBL898371 | 0.79 | LRRK2 (0.48) | LRRK2MAOAMAOBPDGFRAFER | |
| SCHEMBL8123268 | 0.76 | LRRK2 (0.55) | LRRK2MAOAMAOBPDGFRAFER | |
| SCHEMBL102781 | 0.75 | MEN1 (0.37) | MAOAMAOBGSK3BMAPTALDH1A1 | |
| SCHEMBL6255304 | 0.71 | LRRK2 (0.58) | LRRK2MAOAMAOBPDGFRAFER | |
| SCHEMBL577831 | 0.71 | CDC25B (0.58) | MAOAMAOBMAPTALDH1A1NPSR1 | |
| SCHEMBL577541 | 0.68 | GAA (0.43) | LRRK2MAOAMAOBPDGFRAFER | |
| SCHEMBL577542 | 0.68 | GAA (0.43) | LRRK2MAOAMAOBPDGFRAFER | |
| SCHEMBL17816635 | 0.67 | LRRK2 (0.59) | LRRK2MAOAMAOBPDGFRAFER | |
| SCHEMBL30462618 | 0.67 | LRRK2 (0.59) | LRRK2MAOAMAOBPDGFRAFER |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2109604-A1 | 6-OXO-6,7-DIHYDRO-5H-DIBENZO[B,D]AZEPIN-7-YL DERIVATIVES | F. Hoffmann-Roche AG (CH) | 2009-10-21 | — | — | EP | claimed |
| WO-2008092786-A1 | 6-OXO-6,7-DIHYDRO-5H-DIBENZO[B,D]AZEPIN-7-YL DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2008-08-07 | — | — | WO | claimed |
| CN-101622232-A | 6-oxo-6, 7-dihydro-5H-dibenzo [B, D] aza-7-yl derivative | HOFFMANN LA ROCHE | 2010-01-06 | — | — | CN | disclosed |
| EP-2109604-A1 | 6-OXO-6,7-DIHYDRO-5H-DIBENZO[B,D]AZEPIN-7-YL DERIVATIVES | F. Hoffmann-Roche AG (CH) | 2009-10-21 | — | — | EP | disclosed |
| EP-2109604-A1 | 6-OXO-6,7-DIHYDRO-5H-DIBENZO[B,D]AZEPIN-7-YL DERIVATIVES | F. Hoffmann-Roche AG (CH) | 2009-10-21 | — | — | EP | disclosed |
| US-7544679-B2 | 6-oxo-6,7-dihydro-5h-dibenzo[b,d]azepin-7-yl derivatives | HOFFMAN-LA ROCHE INC. (US) | 2009-06-09 | — | — | US | disclosed |
| US-7544679-B2 | 6-oxo-6,7-dihydro-5h-dibenzo[b,d]azepin-7-yl derivatives | HOFFMAN-LA ROCHE INC. (US) | 2009-06-09 | — | — | US | disclosed |
| US-7544679-B2 | 6-oxo-6,7-dihydro-5h-dibenzo[b,d]azepin-7-yl derivatives | HOFFMAN-LA ROCHE INC. (US) | 2009-06-09 | — | — | US | disclosed |
| WO-2008092786-A1 | 6-OXO-6,7-DIHYDRO-5H-DIBENZO[B,D]AZEPIN-7-YL DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2008-08-07 | — | — | WO | disclosed |
| WO-2008092786-A1 | 6-OXO-6,7-DIHYDRO-5H-DIBENZO[B,D]AZEPIN-7-YL DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2008-08-07 | — | — | WO | disclosed |
| US-20080188463-A1 | 6-OXO-6,7-DIHYDRO-5H-DIBENZO[B,D]AZEPIN-7-YL DERIVATIVES | HOFFMANN-LA ROCHE, INC. | 2008-08-07 | — | — | US | disclosed |
| US-20080188463-A1 | 6-OXO-6,7-DIHYDRO-5H-DIBENZO[B,D]AZEPIN-7-YL DERIVATIVES | HOFFMANN-LA ROCHE, INC. | 2008-08-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080188463-A1 | 6-OXO-6,7-DIHYDRO-5H-DIBENZO[B,D]AZEPIN-7-YL DERIVATIVES | BACE1, BACE2, APH1B | LRRK2 2430/4885MAOA 2744/4885MAOB 1812/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.