Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 14/20 | 0.68 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.59 |
| ▸ | CSF1R | P07333 | 4/20 | 0.58 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | KIT | P10721 | 1/20 | 0.50 |
| ▸ | KDR | P35968 | 1/20 | 0.50 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3932800 | 0.85 | BRAF (0.75) | BRAFL3MBTL1CSF1RMAPTKIT | |
| SCHEMBL21844938 | 0.82 | LMNA (0.50) | MAPT | |
| SCHEMBL3933255 | 0.81 | BRAF (1.00) | BRAFL3MBTL1CSF1RMAPTKIT | |
| SCHEMBL3933045 | 0.81 | BRAF (1.00) | BRAFL3MBTL1CSF1RMAPTKIT | |
| SCHEMBL15276911 | 0.79 | SIRT2 (0.51) | L3MBTL1MAPT | |
| SCHEMBL15276914 | 0.79 | LMNA (0.58) | L3MBTL1MAPT | |
| SCHEMBL3935822 | 0.78 | BRAF (0.72) | BRAFL3MBTL1CSF1RMAPTKIT | |
| SCHEMBL3934184 | 0.77 | BRAF (1.00) | BRAFCSF1RKITKDRMAPK14 | |
| SCHEMBL3944151 | 0.77 | BRAF (0.77) | BRAFCSF1RKITKDRMAPK14 | |
| SCHEMBL3941970 | 0.76 | L3MBTL1 (0.79) | BRAFL3MBTL1CSF1RMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1831198-B1 | PYRIDINE CARBOXAMIDE DERIVATIVES FOR USE AS ANTICANCER AGENTS | ASTRAZENECA AB (SE) | 2009-04-08 | — | — | EP | disclosed |