Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.79 |
| ▸ | BRAF | P15056 | 7/20 | 0.64 |
| ▸ | MAPT | P10636 | 2/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.58 |
| ▸ | MEN1 | O00255 | 2/20 | 0.58 |
| ▸ | LMNA | P02545 | 2/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | CSF1R | P07333 | 6/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3941970 | 0.89 | L3MBTL1 (0.79) | L3MBTL1BRAFMAPTALDH1A1MEN1 | |
| SCHEMBL3931681 | 0.84 | BRAF (0.79) | BRAFCSF1R | |
| SCHEMBL3935559 | 0.83 | BRAF (0.80) | BRAFCSF1R | |
| SCHEMBL3931363 | 0.82 | CSF1R (0.80) | BRAFCSF1R | |
| SCHEMBL3936478 | 0.81 | CSF1R (0.81) | L3MBTL1BRAFMEN1KMT2ACSF1R | |
| SCHEMBL3937125 | 0.81 | CSF1R (0.79) | BRAFMAPTMEN1KMT2ACSF1R | |
| SCHEMBL4020844 | 0.81 | CSF1R (0.64) | BRAFCSF1R | |
| SCHEMBL3941905 | 0.81 | CSF1R (0.77) | BRAFMEN1KMT2ACSF1R | |
| SCHEMBL3932800 | 0.80 | BRAF (0.75) | L3MBTL1BRAFMAPTCSF1R | |
| SCHEMBL3944890 | 0.80 | CSF1R (0.78) | BRAFALDH1A1KMT2ASMN1; SMN2CSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1831198-B1 | PYRIDINE CARBOXAMIDE DERIVATIVES FOR USE AS ANTICANCER AGENTS | ASTRAZENECA AB (SE) | 2009-04-08 | — | — | EP | disclosed |