Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.40 |
| ▸ | HTT | P42858 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 4/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | RAF1 | P04049 | 1/20 | 0.37 |
| ▸ | BRAF | P15056 | 1/20 | 0.37 |
| ▸ | CASP3 | P42574 | 1/20 | 0.37 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.37 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.37 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13942589 | 0.92 | TSHR (0.45) | SMN1; SMN2HTTALDH1A1TSHRPKM | |
| SCHEMBL3942061 | 0.92 | TSHR (0.45) | SMN1; SMN2HTTALDH1A1TSHRPKM | |
| SCHEMBL3950666 | 0.91 | LMNA (0.44) | SMN1; SMN2HTTALDH1A1TSHRPKM | |
| SCHEMBL3941659 | 0.89 | HTT (0.49) | SMN1; SMN2HTTALDH1A1TSHRPKM | |
| SCHEMBL3950731 | 0.88 | PKM (0.38) | SMN1; SMN2HTTALDH1A1TSHRPKM | |
| SCHEMBL3947163 | 0.86 | LMNA (0.40) | HTTTSHRLMNAKMT2AMEN1 | |
| SCHEMBL3942854 | 0.84 | PKM (0.55) | SMN1; SMN2HTTALDH1A1TSHRPKM | |
| SCHEMBL4101784 | 0.84 | LMNA (0.45) | SMN1; SMN2HTTALDH1A1TSHRPKM | |
| SCHEMBL3940676 | 0.84 | HTT (0.40) | SMN1; SMN2HTTALDH1A1TSHRPKM | |
| SCHEMBL3950817 | 0.81 | TSHR (0.39) | SMN1; SMN2HTTALDH1A1TSHRPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009020457-A2 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-02-12 | — | — | WO | disclosed |
| WO-2009020457-A2 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-02-12 | — | — | WO | disclosed |