Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | DPP4 | P27487 | 4/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.42 |
| ▸ | DPP7 | Q9UHL4 | 4/20 | 0.42 |
| ▸ | STS | P08842 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | CTSL | P07711 | 1/20 | 0.41 |
| ▸ | CTSB | P07858 | 1/20 | 0.41 |
| ▸ | CTSK | P43235 | 1/20 | 0.41 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.41 |
| ▸ | YAP1 | P46937 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | KDM1A | O60341 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7870 | 0.80 | L3MBTL1 (0.58) | HSD11B1L3MBTL1DPP4KCNH2DPP7 | |
| SCHEMBL30121231 | 0.79 | L3MBTL1 (0.51) | HSD11B1L3MBTL1DPP4KCNH2DPP7 | |
| SCHEMBL3726979 | 0.78 | HSD11B1 (0.65) | HSD11B1L3MBTL1DPP4KCNH2DPP7 | |
| SCHEMBL951887 | 0.78 | HSD11B1 (0.65) | HSD11B1L3MBTL1DPP4KCNH2DPP7 | |
| SCHEMBL6944572 | 0.78 | HSD11B1 (0.65) | HSD11B1L3MBTL1DPP4KCNH2DPP7 | |
| SCHEMBL26618839 | 0.78 | STS (0.47) | HSD11B1L3MBTL1DPP4KCNH2DPP7 | |
| SCHEMBL29691239 | 0.78 | ENPP2 (0.49) | HSD11B1L3MBTL1DPP4KCNH2DPP7 | |
| SCHEMBL24041196 | 0.77 | STS (0.46) | HSD11B1L3MBTL1STSALDH1A1MAPT | |
| SCHEMBL4367160 | 0.77 | STS (0.48) | HSD11B1L3MBTL1STSALDH1A1GAA | |
| SCHEMBL2521762 | 0.77 | EPHX1 (0.57) | HSD11B1L3MBTL1DPP4KCNH2DPP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009034546-A2 | TRANS-DECAHYDROISOQUINOLINE DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2009-03-19 | — | — | WO | disclosed |