SCHEMBL7870

SCHEMBL7870

CC(C)(C)OC(=O)N1CCC(NC(=O)OCc2ccccc2)CC1

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 1/20 0.58
ALDH1A1 P00352 2/20 0.57
GAA P10253 1/20 0.57
MAPT P10636 2/20 0.56
MAPK1 P28482 2/20 0.56
NPSR1 Q6W5P4 2/20 0.56
NTSR1 P30989 1/20 0.56
HSD11B1 P28845 1/20 0.56
MEN1 O00255 2/20 0.56
KMT2A Q03164 2/20 0.56
CTSL P07711 1/20 0.56
CTSB P07858 1/20 0.56
CTSK P43235 1/20 0.56
STS P08842 1/20 0.55
EPHX1 P07099 1/20 0.55
POLB P06746 1/20 0.55
TSHR P16473 1/20 0.55
NPC1 O15118 1/20 0.54
RAB9A P51151 1/20 0.54
SMN1; SMN2 Q16637 1/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2526123 0.96 EPHX1 (0.57) L3MBTL1ALDH1A1GAAMAPTMAPK1
SCHEMBL2521760 0.96 EPHX1 (0.57) L3MBTL1ALDH1A1GAAMAPTMAPK1
SCHEMBL2521762 0.96 EPHX1 (0.57) L3MBTL1ALDH1A1GAAMAPTMAPK1
SCHEMBL3726979 0.93 HSD11B1 (0.65) L3MBTL1ALDH1A1GAAMAPTMAPK1
SCHEMBL951887 0.93 HSD11B1 (0.65) L3MBTL1ALDH1A1GAAMAPTMAPK1
SCHEMBL6944572 0.93 HSD11B1 (0.65) L3MBTL1ALDH1A1GAAMAPTMAPK1
SCHEMBL29260022 0.92 YAP1 (0.53) L3MBTL1ALDH1A1GAAMAPTMAPK1
SCHEMBL30750698 0.92 L3MBTL1 (0.52) L3MBTL1ALDH1A1GAAMAPTMAPK1
SCHEMBL26757387 0.91 STS (0.52) L3MBTL1ALDH1A1GAAMAPTMAPK1
SCHEMBL30965834 0.91 KDM4E (0.53) L3MBTL1ALDH1A1GAAMAPTMAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 71 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240360149-A1 COMPOUND WITH ANTICANCER ACTIVITY KYOWA KIRIN CO., LTD. (JP) 2024-10-31 US disclosed
US-20240343733-A1 COMPOUNDS FOR TARGETING DEGRADATION OF IRAK4 PROTEINS C4 THERAPEUTICS, INC. 2024-10-17 US disclosed
US-12054494-B2 Compound with anticancer activity KYOWA KIRIN CO., LTD. (JP) 2024-08-06 US disclosed
CN-117940414-A Compounds for targeting IRAK4 protein degradation 渤健马萨诸塞州股份有限公司 2024-04-26 CN disclosed
EP-3778573-B1 COMPOUND WITH ANTICANCER ACTIVITY KYOWA KIRIN CO LTD (JP) 2024-04-24 EP disclosed
CN-111936468-B Compounds with anticancer activity 协和麒麟株式会社 2024-03-08 CN disclosed
US-20230174487-A1 PHENYLPROPIONAMIDE COMPOUND AND USE THEREOF MEDSHINE DISCOVERY INC. (CN) 2023-06-08 US disclosed
US-20230174487-A1 PHENYLPROPIONAMIDE COMPOUND AND USE THEREOF MEDSHINE DISCOVERY INC. (CN) 2023-06-08 US disclosed
US-20230159554-A1 COMPOUND WITH ANTICANCER ACTIVITY KYOWA KIRIN CO., LTD. (JP) 2023-05-25 US disclosed
US-11629152-B2 Compound with anticancer activity KYOWA KIRIN CO., LTD. (JP) 2023-04-18 US disclosed
US-20020193614-A1 Anthranilic acid derivatives as inhibitors of the CGMP-phosphodiesterase FUJISAWA PHARMACEUTICAL CO. LTD. (JP) 2002-12-19 US disclosed
US-6476054-B1 Cyclic amine modulators of chemokine receptor activity MERCK & CO., INC. 2002-11-05 US disclosed
US-6472410-B1 N-cyclopentyl modulators of chemokine receptor activity MERCK & CO., INC. 2002-10-29 US disclosed
US-6384080-B1 TREATMENT AND/OR PREVENTION OF CERTAIN CARDIOVASCULAR DISORDERS, UROGENITAL DISORDERS, RESPIRATORY SYSTEM DISORDERS, DISORDERS OF GUT MOTILITY, SEXUAL DISORDERS, DIABETIC COMPLICATIONS, URTICARIA FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2002-05-07 US disclosed
CN-1305454-A Anthranilic acid derivatives as inhibitors of CGMP phosphodiesterase FUJISAWA PHARMACEUTICAL CO (JP) 2001-07-25 CN disclosed
WO-2000076512-A1 CYCLOPENTYL MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY MERCK & CO., INC. (US) 2000-12-21 WO disclosed
US-6140349-A FOR PROPHYLAXIS AND THERAPY OF HUMAN IMMUNODEFICIENCY VIRUS(HIV) INFECTIONS AND ACQUIRED IMMUNODEDICIENCY SYNDROME MERCK & CO., INC. (US) 2000-10-31 US disclosed
US-6136827-A PIPERIDINE COMPOUNDS AS DRUGS MERCK & CO., INC. (US) 2000-10-24 US disclosed
EP-1003514-A1 CYCLIC AMINE MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY Merck & Co., Inc. (US) 2000-05-31 EP disclosed
WO-1999004794-A1 CYCLIC AMINE MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY MERCK & CO., INC. (US) 1999-02-04 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020193614-A1 Anthranilic acid derivatives as inhibitors of the CGMP-phosphodiesterase PDE3A, PDE2A, PDE5A L3MBTL1 4716/4885ALDH1A1 253/4885GAA 68/4885
US-12054494-B2 Compound with anticancer activity TP53, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, RCC2 L3MBTL1 631/4885ALDH1A1 199/4885GAA 264/4885
US-20230159554-A1 COMPOUND WITH ANTICANCER ACTIVITY TP53, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, RCC2 L3MBTL1 631/4885ALDH1A1 199/4885GAA 264/4885
US-20230174487-A1 PHENYLPROPIONAMIDE COMPOUND AND USE THEREOF PAH, TRPV1, TRPA1 L3MBTL1 4478/4885ALDH1A1 399/4885GAA 803/4885
US-11629152-B2 Compound with anticancer activity TP53, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, RCC2 L3MBTL1 631/4885ALDH1A1 199/4885GAA 264/4885
US-20240343733-A1 COMPOUNDS FOR TARGETING DEGRADATION OF IRAK4 PROTEINS IRAK4, IRAK2, IRAK1 L3MBTL1 1060/4885ALDH1A1 2273/4885GAA 1356/4885
US-20240360149-A1 COMPOUND WITH ANTICANCER ACTIVITY TP53, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, RCC2 L3MBTL1 631/4885ALDH1A1 199/4885GAA 264/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.