Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | ADORA2B | P29275 | 3/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3947142 | 0.86 | MEN1 (0.53) | MEN1KMT2AALDH1A1TP53KDM4E | |
| SCHEMBL13942611 | 0.86 | MEN1 (0.51) | MEN1KMT2AALDH1A1TP53KDM4E | |
| SCHEMBL3950394 | 0.85 | MEN1 (0.56) | HTTMEN1KMT2AALDH1A1TP53 | |
| SCHEMBL3944408 | 0.83 | TSHR (0.49) | HTTADORA2BTP53 | |
| SCHEMBL3951091 | 0.83 | HTT (0.43) | HTTMEN1KMT2ATP53KDM4E | |
| SCHEMBL13942605 | 0.82 | TSHR (0.52) | HTTMEN1KMT2AALDH1A1TP53 | |
| SCHEMBL3944971 | 0.81 | MEN1 (0.48) | HTTMEN1KMT2AALDH1A1TP53 | |
| SCHEMBL3943138 | 0.81 | RXFP1 (0.55) | MEN1KMT2AALDH1A1 | |
| SCHEMBL13942363 | 0.81 | ADORA2B (0.55) | MEN1KMT2AADORA2B | |
| SCHEMBL13942609 | 0.80 | PKM (0.52) | MEN1KMT2AALDH1A1TP53KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009020457-A2 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-02-12 | — | — | WO | disclosed |
| WO-2009020457-A2 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-02-12 | — | — | WO | disclosed |