Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.33 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 3/20 | 0.32 |
| ▸ | MEN1 | O00255 | 3/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.32 |
| ▸ | GAA | P10253 | 2/20 | 0.31 |
| ▸ | GLA | P06280 | 1/20 | 0.31 |
| ▸ | RECQL | P46063 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.31 |
| ▸ | RELA | Q04206 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.30 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3822276 | 0.72 | MAPK10 (0.36) | KDM4EMAPK10SLC40A1 | |
| SCHEMBL5074316 | 0.70 | MAPK10 (0.51) | MAPK10MAPTMEN1KMT2AGAA | |
| SCHEMBL14048610 | 0.69 | MEN1 (0.65) | KDM4EMAPTMEN1KMT2AGAA | |
| SCHEMBL445017 | 0.69 | MAPT (0.48) | KDM4EMAPTMEN1KMT2AGAA | |
| SCHEMBL25167315 | 0.67 | ADRA2A (0.56) | KDM4EMAPTMEN1KMT2AGAA | |
| SCHEMBL5006940 | 0.66 | MAPT (0.50) | KDM4EMAPTMEN1KMT2AGAA | |
| Hydrochloric Acid SCHEMBL4594657 | 0.65 | MAPT (0.48) | KDM4EMAPTMEN1KMT2AGAA | |
| SCHEMBL6625263 | 0.64 | TDP1 (0.38) | KDM4ESLC40A1MAPTMEN1KMT2A | |
| SCHEMBL8852094 | 0.64 | IDO1 (0.57) | KDM4ESLC40A1MAPTMEN1KMT2A | |
| SCHEMBL30366540 | 0.64 | HPRT1 (0.46) | KDM4EMAPTGAATDP1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2049507-A2 | MODULATORS OF GLUCOCORTICOID RECEPTOR, AND/OR AP-1, AND/OR NF-KB ACTIVITY AND USE THEREOF | Brystol-Myers Squibb Company (US) | 2009-04-22 | — | — | EP | disclosed |
| WO-2008021926-A2 | MODULATORS OF GLUCOCORTICOID RECEPTOR, AND/OR AP-1, AND/OR NF-KB ACTIVITY AND USE THEREOF | BRISTOL-MYERS SQUIBB COMPANY (US) | 2008-02-21 | — | — | WO | disclosed |