SCHEMBL3945152

SCHEMBL3945152

ClCCCCOc1cccc(-c2cs[c]n2)c1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 1/20 0.40
CYP1A2 P05177 1/20 0.39
CYP19A1 P11511 1/20 0.39
CYP2C9 P11712 1/20 0.39
CYP2C19 P33261 1/20 0.39
KDM4E B2RXH2 1/20 0.38
HRH3 Q9Y5N1 1/20 0.38
DHODH Q02127 1/20 0.37
ADORA2A P29274 1/20 0.36
HDAC1 Q13547 5/20 0.36
HDAC2 Q92769 5/20 0.36
HDAC8 Q9BY41 4/20 0.36
HDAC6 Q9UBN7 4/20 0.36
HDAC3 O15379 1/20 0.36
HDAC4 P56524 1/20 0.36
HDAC7 Q8WUI4 1/20 0.36
HDAC10 Q969S8 1/20 0.36
HDAC11 Q96DB2 1/20 0.36
HDAC9 Q9UKV0 1/20 0.36
HDAC5 Q9UQL6 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17626100 0.86 ALDH1A1 (0.42) SMN1; SMN2CYP1A2CYP19A1CYP2C9CYP2C19
SCHEMBL3949019 0.83 LTB4R (0.38) SMN1; SMN2CYP1A2CYP19A1CYP2C9CYP2C19
SCHEMBL17626237 0.83 MAPT (0.49) SMN1; SMN2KDM4ETSHRGAAMAPT
SCHEMBL500272 0.77 CYP19A1 (0.49) SMN1; SMN2CYP19A1KDM4EGAAMAPT
SCHEMBL17625946 0.76 CTSS (0.48) ADORA2A
SCHEMBL10674759 0.73 HRH3 (0.57) HRH3HDAC1HDAC2HDAC8HDAC6
SCHEMBL10678823 0.72 RXRA (0.51) CYP1A2CYP19A1CYP2C9CYP2C19KDM4E
SCHEMBL11233038 0.72 KCNA3 (0.54) CYP1A2CYP2C19KDM4ETSHR
SCHEMBL10671455 0.71 HRH3 (0.60) HRH3HDAC1HDAC2HDAC8HDAC6
SCHEMBL10678085 0.71 HRH3 (0.60) HRH3HDAC1HDAC2HDAC8HDAC6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2010508-A1 THIAZOL-GUANIDINE DERIVATIVES USEFUL AS A (BETA)- RELATED PATHOLOGIES AstraZeneca AB (SE) 2009-01-07 EP disclosed
WO-2007120096-A1 THIAZOL-GUANIDINE DERIVATIVES USEFUL AS A (BETA)- RELATED PATHOLOGIES ASTRAZENECA AB (SE) 2007-10-25 WO disclosed