Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | TUBB4A | P04350 | 6/20 | 0.39 |
| ▸ | TUBB | P07437 | 6/20 | 0.39 |
| ▸ | TUBA3C | P0DPH7 | 6/20 | 0.39 |
| ▸ | TUBA1B | P68363 | 6/20 | 0.39 |
| ▸ | TUBA4A | P68366 | 6/20 | 0.39 |
| ▸ | TUBB4B | P68371 | 6/20 | 0.39 |
| ▸ | TUBB3 | Q13509 | 6/20 | 0.39 |
| ▸ | TUBB2A | Q13885 | 6/20 | 0.39 |
| ▸ | TUBB8 | Q3ZCM7 | 6/20 | 0.39 |
| ▸ | TUBA3E | Q6PEY2 | 6/20 | 0.39 |
| ▸ | TUBA1A | Q71U36 | 6/20 | 0.39 |
| ▸ | TUBA1C | Q9BQE3 | 6/20 | 0.39 |
| ▸ | TUBB6 | Q9BUF5 | 6/20 | 0.39 |
| ▸ | TUBB2B | Q9BVA1 | 6/20 | 0.39 |
| ▸ | TUBB1 | Q9H4B7 | 6/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3944030 | 0.91 | ALDH1A1 (0.46) | MAPTALDH1A1GAATUBB4ATUBB | |
| SCHEMBL3953367 | 0.88 | MAPT (0.40) | MAPTALDH1A1GAATUBB4ATUBB | |
| SCHEMBL3944999 | 0.86 | MAPT (0.57) | MAPTALDH1A1GAATP53 | |
| SCHEMBL3944758 | 0.78 | ALDH1A1 (0.43) | MAPTALDH1A1GAAKMT2AMEN1 | |
| SCHEMBL3946003 | 0.74 | TUBB4A (0.43) | ALDH1A1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL3943568 | 0.72 | HTT (0.39) | ALDH1A1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL3953363 | 0.71 | ALDH1A1 (0.38) | MAPTALDH1A1GAATUBB4ATUBB | |
| SCHEMBL3952229 | 0.71 | MAPT (0.50) | MAPTALDH1A1GAAKMT2ATP53 | |
| SCHEMBL3952764 | 0.71 | KMT2A (0.35) | MAPTALDH1A1KMT2ATP53MEN1 | |
| SCHEMBL3944692 | 0.70 | L3MBTL1 (0.40) | ALDH1A1KMT2AMEN1KDM4ENPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7553845-B2 | Substituted indolizine 1,2,3,6,7,8 derivatives, FGFs inhibitors, a method for the preparation thereof and pharmaceutical compositions containing said derivatives | SANOFI-AVENTIS (FR) | 2009-06-30 | — | — | US | disclosed |
| US-20060199962-A1 | Substituted indolizine 1,2,3,6,7,8 derivatives, FGFs inhibitors, a method for the preparation thereof and pharmaceutical compositions containing said derivatives | SANOFI-AVENTIS (FR) | 2006-09-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060199962-A1 | Substituted indolizine 1,2,3,6,7,8 derivatives, FGFs inhibitors, a method for the preparation thereof and pharmaceutical compositions containing said derivatives | FGF1, FGF2, FGFR1 | MAPT 2703/4885ALDH1A1 724/4885GAA 3531/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.