Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 1/20 | 0.40 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.39 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 5/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 4/20 | 0.33 |
| ▸ | CNR1 | P21554 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | BTK | Q06187 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3943459 | 0.81 | BRAF (0.33) | HTTMAPTKMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL17626272 | 0.81 | HTT (0.60) | HTTSMN1; SMN2ALDH1A1MAPK1BRD4 | |
| SCHEMBL17626118 | 0.81 | MAPT (0.35) | HTTMAPTKMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL17626108 | 0.80 | KIF11 (0.40) | MAPTKMT2ASMN1; SMN2MEN1TSHR | |
| SCHEMBL1915009 | 0.78 | IDO1 (0.45) | MAPTKMT2ASMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL3949513 | 0.76 | ADRA2A (0.43) | MAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL468087 | 0.75 | CYP19A1 (0.45) | MAPTSMN1; SMN2MAPK1 | |
| SCHEMBL6050957 | 0.75 | KDM4E (0.51) | MAPTKMT2AALDH1A1MEN1KDM4E | |
| SCHEMBL7228532 | 0.75 | RAB9A (0.51) | MAPTKMT2ASMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL4711911 | 0.75 | RECQL (0.50) | MAPTKMT2ASMN1; SMN2ALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2010508-A1 | THIAZOL-GUANIDINE DERIVATIVES USEFUL AS A (BETA)- RELATED PATHOLOGIES | AstraZeneca AB (SE) | 2009-01-07 | — | — | EP | claimed |
| WO-2007120096-A1 | THIAZOL-GUANIDINE DERIVATIVES USEFUL AS A (BETA)- RELATED PATHOLOGIES | ASTRAZENECA AB (SE) | 2007-10-25 | — | — | WO | claimed |