Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 1/20 | 0.33 |
| ▸ | CNR1 | P21554 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.32 |
| ▸ | MEN1 | O00255 | 4/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.32 |
| ▸ | OTUD7B | Q6GQQ9 | 1/20 | 0.31 |
| ▸ | JAK2 | O60674 | 1/20 | 0.31 |
| ▸ | JAK3 | P52333 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | CTSS | P25774 | 4/20 | 0.30 |
| ▸ | CTSK | P43235 | 4/20 | 0.30 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3947270 | 0.81 | PLK1 (0.40) | CNR1HTTKMT2AMEN1ALDH1A1 | |
| SCHEMBL11507047 | 0.76 | HSD17B1 (0.49) | HTTKMT2AMEN1ALDH1A1MAPT | |
| SCHEMBL17626272 | 0.75 | HTT (0.60) | HTTALDH1A1MAPK1SMN1; SMN2JAK2 | |
| SCHEMBL17626118 | 0.75 | MAPT (0.35) | HTTKMT2AMEN1ALDH1A1MAPT | |
| SCHEMBL3949513 | 0.73 | ADRA2A (0.43) | ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL7228532 | 0.72 | RAB9A (0.51) | KMT2AMEN1ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL468087 | 0.72 | CYP19A1 (0.45) | MAPTMAPK1SMN1; SMN2CTSSCTSK | |
| SCHEMBL6050957 | 0.72 | KDM4E (0.51) | KMT2AMEN1ALDH1A1MAPT | |
| SCHEMBL1915009 | 0.72 | IDO1 (0.45) | KMT2AMEN1ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL4711911 | 0.72 | RECQL (0.50) | KMT2AMEN1ALDH1A1MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2010508-A1 | THIAZOL-GUANIDINE DERIVATIVES USEFUL AS A (BETA)- RELATED PATHOLOGIES | AstraZeneca AB (SE) | 2009-01-07 | — | — | EP | claimed |
| WO-2007120096-A1 | THIAZOL-GUANIDINE DERIVATIVES USEFUL AS A (BETA)- RELATED PATHOLOGIES | ASTRAZENECA AB (SE) | 2007-10-25 | — | — | WO | claimed |
| EP-2010508-A1 | THIAZOL-GUANIDINE DERIVATIVES USEFUL AS A (BETA)- RELATED PATHOLOGIES | AstraZeneca AB (SE) | 2009-01-07 | — | — | EP | disclosed |
| WO-2007120096-A1 | THIAZOL-GUANIDINE DERIVATIVES USEFUL AS A (BETA)- RELATED PATHOLOGIES | ASTRAZENECA AB (SE) | 2007-10-25 | — | — | WO | disclosed |