Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 5/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.50 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.41 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.41 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.41 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | ESR1 | P03372 | 1/20 | 0.33 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18810810 | 0.76 | CYP3A4 (0.43) | CYP3A4CYP2C19CYP1A2CYP2C9CYP19A1 | |
| SCHEMBL2334995 | 0.76 | CYP3A4 (0.41) | CYP3A4CYP2C19CYP1A2CYP2C9CYP19A1 | |
| SCHEMBL23172374 | 0.75 | AOC3 (0.47) | CYP3A4CYP2C19CYP2C9SLC6A4KDM4E | |
| SCHEMBL7434679 | 0.75 | AOC3 (0.47) | CYP3A4CYP2C19CYP2C9SLC6A4KDM4E | |
| SCHEMBL4372186 | 0.75 | AOC3 (0.47) | CYP3A4CYP2C19CYP2C9SLC6A4KDM4E | |
| SCHEMBL11228787 | 0.74 | SMN1; SMN2 (0.55) | CYP19A1CYP17A1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL76211 | 0.73 | TSHR (0.58) | CYP2C19CYP2C9CYP19A1LMNAESR1 | |
| SCHEMBL7120983 | 0.73 | ESR1 (0.62) | CYP3A4CYP2C19CYP1A2CYP2C9CYP19A1 | |
| SCHEMBL23149886 | 0.73 | CES2 (0.53) | — | |
| SCHEMBL23958361 | 0.73 | CYP19A1 (0.41) | CYP3A4CYP2C19CYP1A2CYP2C9CYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7572905-B1 | Apoptotic protease activating factor 1 (APAF1) gene, some mutant alleles of which cause susceptibility to depression | MYRIAD GENETICS, INC. (US) | 2009-08-11 | — | — | US | disclosed |