Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 1.00 |
| ▸ | MAPT | P10636 | 2/20 | 0.72 |
| ▸ | LMNA | P02545 | 2/20 | 0.68 |
| ▸ | HTT | P42858 | 1/20 | 0.67 |
| ▸ | RAB9A | P51151 | 4/20 | 0.56 |
| ▸ | NPC1 | O15118 | 3/20 | 0.56 |
| ▸ | THRB | P10828 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | PKM | P14618 | 2/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11717438 | 0.86 | ALDH1A1 (0.75) | ALDH1A1KDM4EMAPTLMNAHTT | |
| SCHEMBL11716910 | 0.82 | ALDH1A1 (0.69) | ALDH1A1KDM4EMAPTLMNAHTT | |
| SCHEMBL11722203 | 0.81 | ALDH1A1 (0.68) | ALDH1A1KDM4EMAPTLMNAHTT | |
| SCHEMBL3947661 | 0.81 | MAPT (0.78) | ALDH1A1KDM4EMAPTLMNAHTT | |
| SCHEMBL11713302 | 0.73 | ALDH1A1 (0.57) | ALDH1A1KDM4EMAPTLMNAHTT | |
| SCHEMBL11713346 | 0.72 | POLB (0.63) | ALDH1A1KDM4EMAPTLMNAHTT | |
| SCHEMBL6406874 | 0.71 | LMNA (0.65) | ALDH1A1KDM4ELMNAHTTRAB9A | |
| SCHEMBL11720825 | 0.70 | ALDH1A1 (0.54) | ALDH1A1KDM4EMAPTLMNAHTT | |
| SCHEMBL10599397 | 0.70 | POLB (0.65) | ALDH1A1KDM4EMAPTLMNAHTT | |
| SCHEMBL6403164 | 0.68 | LMNA (0.65) | ALDH1A1KDM4ELMNAHTTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7485639-B2 | 4-(benzylidene-amino)-3-(methylsulfanyl)-4h-(1,2,4)triazin-5-one derivatives having a PDE-IV inhibiting and TNF-antagonistic effect for the treatment of cardiac diseases and allergies | MERCK PATENT GMBH (DE) | 2009-02-03 | — | — | US | disclosed |
| EP-1406878-B1 | 4-(BENZYLIDENE-AMINO)-3-(METHYLSULFANYL)-4H-(1, 2, 4) TRIAZIN-5-ONE DERIVATIVES HAVING A PDE-IV INHIBITING AND TNF-ANTAGONISTIC EFFECT FOR THE TREATMENT OF CARDIAC DISEASES AND ALLERGIES | MERCK PATENT GMBH (DE) | 2006-06-07 | — | — | EP | disclosed |
| US-20040176252-A1 | 4-(Benzylidene-amino)-3-methylsulfanyl)-4h-(1,2,4)triazin-5-one derivatives having a pde-iv inhibiting and tnf-antagonistic effect for the treatment of cardiac diseases and allergies | MERCK PATENT GMBH (DE) | 2004-09-09 | — | — | US | disclosed |
| EP-1406878-A1 | 4-(BENZYLIDENE-AMINO)-3-(METHYLSULFANYL)-4H-(1, 2, 4) TRIAZIN-5-ONE DERIVATIVES HAVING A PDE-IV INHIBITING AND TNF-ANTAGONISTIC EFFECT FOR THE TREATMENT OF CARDIAC DISEASES AND ALLERGIES | MERCK PATENT GmbH (DE) | 2004-04-14 | — | — | EP | disclosed |
| WO-2003008392-A1 | 4-(BENZYLIDENE-AMINO)-3-(METHYLSULFANYL)-4H-(1, 2, 4) TRIAZIN-5-ONE DERIVATIVES HAVING A PDE-IV INHIBITING AND TNF-ANTAGONISTIC EFFECT FOR THE TREATMENT OF CARDIAC DISEASES AND ALLERGIES | MERCK PATENT GMBH (DE) | 2003-01-30 | — | — | WO | disclosed |
| US-4346220-A | PRE- AND POSTEMERGENCE HERBICIDES | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1982-08-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040176252-A1 | 4-(Benzylidene-amino)-3-methylsulfanyl)-4h-(1,2,4)triazin-5-one derivatives having a pde-iv inhibiting and tnf-antagonistic effect for the treatment of cardiac diseases and allergies | PDE4A, PDE12, PDE4B | ALDH1A1 1767/4885KDM4E 718/4885MAPT 3123/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.