Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | KDM1A | O60341 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | FAAH | O00519 | 2/20 | 0.35 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.35 |
| ▸ | GNAI3 | P08754 | 1/20 | 0.35 |
| ▸ | GNAO1 | P09471 | 1/20 | 0.35 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7289625 | 0.89 | TSHR (0.56) | TSHRHIF1AALDH1A1FAAHTRPV1 | |
| SCHEMBL3955905 | 0.87 | TSHR (0.48) | TSHRHIF1AALDH1A1FAAHTRPV1 | |
| SCHEMBL2552869 | 0.86 | ALDH1A1 (0.38) | TSHRALDH1A1KDM4EKDM1A | |
| SCHEMBL2592744 | 0.85 | TSHR (0.54) | TSHRKDM4EFAAHTRPV1GNAI3 | |
| SCHEMBL3952508 | 0.84 | PAOX (0.47) | TSHRHIF1AALDH1A1 | |
| SCHEMBL986238 | 0.79 | HRH3 (0.46) | TSHRHIF1AFAAHTRPV1GNAI3 | |
| SCHEMBL984275 | 0.79 | HRH3 (0.46) | TSHRHIF1AFAAHTRPV1GNAI3 | |
| SCHEMBL678406 | 0.79 | HRH3 (0.52) | TSHRHIF1AALDH1A1MAPK1 | |
| SCHEMBL84814 | 0.79 | GNAI3 (0.52) | GNAI3GNAO1GNAI1 | |
| SCHEMBL6663038 | 0.79 | GNAI3 (0.52) | GNAI3GNAO1GNAI1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009024825-A1 | 2-PYRAZINYLBENZIMIDAZOLE DERIVATIVES AS RECEPTOR TYROSINE KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2009-02-26 | — | — | WO | disclosed |