SCHEMBL394820

SCHEMBL394820

Fc1cc(F)ncn1

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Water SCHEMBL9340526 0.96
Water SCHEMBL9340500 0.96 LOXL2 (0.33)
Ether SCHEMBL9340494 0.79 EGFR (0.31)
SCHEMBL18952494 0.78
SCHEMBL17369323 0.78
SCHEMBL13599453 0.78
SCHEMBL1630461 0.78
SCHEMBL21193543 0.78
SCHEMBL21393120 0.73 ALOX5AP (0.30)
SCHEMBL17586506 0.73 CA2 (0.40)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 213 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8101753-B2 Production method of pyrimidine compounds SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2012-01-24 US claimed
EP-1809610-B1 PRODUCTION METHOD OF PYRIMIDINE COMPOUNDS SUMITOMO CHEMICAL CO (JP) 2011-08-24 EP claimed
US-20080039445-A1 PRODUCTION METHOD OF PYRIMIDINE COMPOUNDS SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2008-02-14 US claimed
EP-1809610-A1 PRODUCTION METHOD OF PYRIMIDINE COMPOUNDS Sumitomo Chemical Company, Limited (JP) 2007-07-25 EP claimed
US-7105645-B2 Water-soluble fiber-reactive dyes, method for the production and use thereof DYSTAR TEXTILFARBEN GMBH & CO. DEUTSCHLAND KG (DE) 2006-09-12 US claimed
WO-2006051891-A1 PRODUCTION METHOD OF PYRIMIDINE COMPOUNDS SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2006-05-18 WO claimed
US-20050198748-A1 Copper complexes of monoazo dyes; diazotization of a sulfonyl-o-hydroxyaniline, coupling to a 1-hydroxy-3-sulfonate-6-aminonaphthalene, coppering with copper sulfate pentahydrate; improved washfastness, photostability, and compatibility with other dyes which fix at lower temperatures DYSTAR TEXTILFARBEN GMBH & CO. DEUTSCHLAND KG (DE) 2005-09-15 US claimed
EP-1097970-A2 Water-soluble monoazo compounds, process for their preparation and their use as dyestuffs DyStar Textilfarben GmbH &amp; Co. Deutschland KG (DE) 2001-05-09 EP claimed
US-12545682-B2 Heterocyclic derivatives as P2X7 receptor antagonists BREYE THERAPEUTICS APS (DK) 2026-02-10 US disclosed
EP-4676547-A2 ALPHA-SYNUCLEIN BINDERS AND METHODS OF USE Merck Sharp & Dohme LLC (US) 2026-01-14 EP disclosed
EP-4665331-A1 ALPHA-SYNUCLEIN BINDERS AND METHODS OF USE Merck Sharp & Dohme LLC (US) 2025-12-24 EP disclosed
US-12275728-B2 O-glycoprotein-2-acetamido-2-deoxy-3-D-glucopyranosidase inhibitors BIOGEN MA INC. (US) 2025-04-15 US disclosed
EP-4526303-A1 N6-ADENOSINE-METHYLTRANSFERASE PROTACS AND METHODS OF USE THEREOF University of Zurich (CH) 2025-03-26 EP disclosed
US-20250074922-A1 COMPOUNDS AND METHODS USEFUL FOR STABILIZING PHENYLALANINE HYDROXYLASE MUTATIONS AGIOS PHARMACEUTICALS, INC. 2025-03-06 US disclosed
US-5264440-A Pyrimidinyl ether on methyl acrylate substituted phenyl groups IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1993-11-23 US disclosed
US-5145856-A Fungicides IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1992-09-08 US disclosed
EP-0382375-A2 Fungicides ZENECA LIMITED (GB) 1990-08-16 EP disclosed
EP-0378089-A1 Method for the preparation of 2-amino-4-fluoropyrimidine derivatives BASF Aktiengesellschaft (DE) 1990-07-18 EP disclosed
EP-0055693-A1 Use of phenyl pyrimidines as protecting agents for culture plants against phytotoxic damage caused by herbicides CIBA-GEIGY AG (CH) 1982-07-07 EP disclosed
US-4007164-A FIBER-REACTIVE, CELLULOSE, WOOL BAYER AKTIENGESELLSCHAFT (DT) 1977-02-08 US disclosed