Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | PABPC1 | P11940 | 2/20 | 0.32 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.32 |
| ▸ | METAP1 | P53582 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.32 |
| ▸ | SCD | O00767 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3944673 | 0.79 | AAK1 (0.39) | BRD9MEN1KMT2AAAK1MAPT | |
| SCHEMBL8288755 | 0.78 | ATR (0.34) | MEN1KMT2AAAK1PABPC1METAP1 | |
| SCHEMBL3945475 | 0.77 | EGFR (0.34) | MAPTSMN1; SMN2LMNA | |
| SCHEMBL15812122 | 0.77 | AAK1 (0.37) | BRD9BRD4MEN1KMT2ACNR2 | |
| SCHEMBL6217868 | 0.71 | KMT2A (0.40) | BRD9MEN1KMT2AAAK1MAPT | |
| SCHEMBL29589580 | 0.71 | KMT2A (0.40) | BRD9MEN1KMT2AAAK1MAPT | |
| SCHEMBL7681674 | 0.70 | NNMT (0.47) | BRD9MEN1KMT2AAAK1SMN1; SMN2 | |
| SCHEMBL29713519 | 0.70 | NNMT (0.47) | BRD9MEN1KMT2AAAK1SMN1; SMN2 | |
| SCHEMBL20095986 | 0.69 | MEN1 (0.38) | BRD9MEN1KMT2AAAK1MAPT | |
| SCHEMBL12513167 | 0.69 | ATR (0.38) | BRD9MEN1KMT2AAAK1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009034546-A2 | TRANS-DECAHYDROISOQUINOLINE DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2009-03-19 | — | — | WO | disclosed |