Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATR | Q13535 | 1/20 | 0.34 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.34 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.34 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.34 |
| ▸ | RORC | P51449 | 1/20 | 0.33 |
| ▸ | MMP1 | P03956 | 1/20 | 0.33 |
| ▸ | MMP2 | P08253 | 1/20 | 0.33 |
| ▸ | MMP9 | P14780 | 1/20 | 0.33 |
| ▸ | MMP8 | P22894 | 1/20 | 0.33 |
| ▸ | MMP13 | P45452 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 3/20 | 0.31 |
| ▸ | CA2 | P00918 | 3/20 | 0.31 |
| ▸ | CA12 | O43570 | 2/20 | 0.31 |
| ▸ | CA9 | Q16790 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.31 |
| ▸ | CDK2 | P24941 | 1/20 | 0.31 |
| ▸ | GSK3B | P49841 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3944673 | 0.84 | AAK1 (0.39) | ATRMTNR1AMTNR1BAAK1RORC | |
| SCHEMBL21591739 | 0.83 | MTNR1B (0.41) | MTNR1AMTNR1BCA1CA2CA12 | |
| SCHEMBL15812122 | 0.79 | AAK1 (0.37) | ATRMTNR1AMTNR1BAAK1MEN1 | |
| SCHEMBL3948675 | 0.78 | BRD9 (0.35) | MTNR1AMTNR1BAAK1MEN1PABPC1 | |
| SCHEMBL16307600 | 0.76 | CYP17A1 (0.40) | ATRMETAP1 | |
| SCHEMBL4463941 | 0.76 | LMNA (0.41) | CA1CA12METAP1 | |
| SCHEMBL7681674 | 0.75 | NNMT (0.47) | ATRAAK1CA1CA12CA9 | |
| SCHEMBL29713519 | 0.75 | NNMT (0.47) | ATRAAK1CA1CA12CA9 | |
| SCHEMBL18940331 | 0.74 | POLB (0.47) | MMP1MMP2MMP9MMP8MMP13 | |
| SCHEMBL31309952 | 0.74 | ATR (0.46) | ATRMTNR1ARORCCA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005040168-A1 | AZABENZODIAZEPINES AS PHOSPHODIESTERASE-4 INHIBITORS | WARNER-LAMBERT COMPANY LLC (US) | 2005-05-06 | — | — | WO | disclosed |