SCHEMBL394895

SCHEMBL394895

CS(=O)(=O)Nc1ccc(C=O)cc1

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.61
SMN1; SMN2 Q16637 2/20 0.61
LMNA P02545 2/20 0.61
HPGD P15428 2/20 0.61
KDM4E B2RXH2 1/20 0.61
HTT P42858 1/20 0.61
KEAP1 Q14145 1/20 0.56
CA12 O43570 1/20 0.53
CA1 P00915 1/20 0.53
CA2 P00918 1/20 0.53
CA9 Q16790 1/20 0.53
KIF11 P52732 4/20 0.52
PGR P06401 1/20 0.48
NR3C2 P08235 3/20 0.47
MAPT P10636 1/20 0.47
CYP2C9 P11712 1/20 0.47
CYP2A6 P11509 1/20 0.44
GAA P10253 1/20 0.44
MAPK1 P28482 1/20 0.44
PTGS2 P35354 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8809867 0.94 KIF11 (0.61) ALDH1A1SMN1; SMN2LMNAHPGDKDM4E
SCHEMBL1449931 0.89 PGR (0.67) ALDH1A1SMN1; SMN2LMNAHPGDKDM4E
SCHEMBL14358816 0.84 KEAP1 (0.58) ALDH1A1SMN1; SMN2LMNAHPGDKDM4E
SCHEMBL14358814 0.84 KEAP1 (0.58) ALDH1A1SMN1; SMN2LMNAHPGDKDM4E
SCHEMBL12054668 0.83 KEAP1 (0.75) ALDH1A1SMN1; SMN2LMNAHPGDKDM4E
SCHEMBL5673137 0.83 KEAP1 (0.56) ALDH1A1SMN1; SMN2LMNAHPGDKDM4E
SCHEMBL8017825 0.81 KEAP1 (0.54) ALDH1A1SMN1; SMN2LMNAHPGDKDM4E
SCHEMBL15836266 0.79 KEAP1 (0.52) ALDH1A1SMN1; SMN2LMNAHPGDKDM4E
SCHEMBL3554742 0.79 KEAP1 (0.52) ALDH1A1SMN1; SMN2LMNAHPGDKDM4E
SCHEMBL3059778 0.79 HPGD (0.66) ALDH1A1SMN1; SMN2LMNAHPGDKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 128 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119899122-A Cyclobutylmethyl and phenyl substituted curcumin derivative and preparation method and application thereof 常州大学 2025-04-29 CN claimed
CN-116283676-A Curcumin derivative and preparation method and application thereof 常州大学 2023-06-23 CN claimed
CN-119899122-A Cyclobutylmethyl and phenyl substituted curcumin derivative and preparation method and application thereof 常州大学 2025-04-29 CN disclosed
CN-116283676-B Curcumin derivative and preparation method and application thereof 常州大学 2025-03-28 CN disclosed
EP-2408454-B1 NOVEL ANTI-INFLAMMATORY AGENTS RESVERLOGIX CORP (CA) 2024-07-24 EP disclosed
EP-2984072-B1 SYNTHETIC ANALOGUES OF XANTHOHUMOL UNIV PISA (IT) 2024-05-29 EP disclosed
US-20240139131-A1 SOTALOL COMPOSITIONS AND USES OF THE SAME HPS INVESTMENT PARTNERS, LLC, AS ADMINISTRATIVE AGENT 2024-05-02 US disclosed
US-11850222-B2 Sotalol compositions and uses of the same ARBOR PHARMACEUTICALS, LLC (US) 2023-12-26 US disclosed
US-11802135-B2 Lysophosphatidic acid derivative MITSUBISHI TANABE PHARMA CORPORATION (JP) 2023-10-31 US disclosed
WO-2023154344-A1 2-METHYL-4',5'-DIHYDROSPIRO[PIPERIDINE-4,7'-THIENO[2,3-C]PYRAN] DERIVATIVES AS INHIBITORS OF APOL1 AND METHODS OF USING SAME VERTEX PHARMACEUTICALS INCORPORATED (US) 2023-08-17 WO disclosed
US-11718643-B2 Multimodal anion exchange matrices CYTIVA BIOPROCESS R&D AB (SE) 2023-08-08 US disclosed
EP-0215124-B1 SILVER HALIDE PHOTOGRAPHIC PHOTO-SENSITIVE MATERIAL FUJI PHOTO FILM CO., LTD. (JP) 1991-09-04 EP disclosed
EP-0435561-A2 Silver halide photographic light-sensitive material KONICA CORPORATION (JP) 1991-07-03 EP disclosed
EP-0434413-A1 Silver halide photographic light-sensitive material KONICA CORPORATION (JP) 1991-06-26 EP disclosed
EP-0401709-A2 X-ray photographic material FUJI PHOTO FILM CO., LTD. (JP) 1990-12-12 EP disclosed
US-4925782-A Silver halide photographic light-sensitive element containing water soluble dye compounds FUJI PHOTO FILM CO., LTD. (JP) 1990-05-15 US disclosed
US-4879204-A HIGH CONTRAST FUJI PHOTO FILM CO., LTD. (JP) 1989-11-07 US disclosed
US-4764455-A Color image-forming process FUJI PHOTO FILM CO., LTD. (JP) 1988-08-16 US disclosed
EP-0215124-A1 SILVER HALIDE PHOTOGRAPHIC PHOTO-SENSITIVE MATERIAL FUJI PHOTO FILM CO., LTD. (JP) 1987-03-25 EP disclosed
US-3931142-A Heterocyclic containing disazo compounds CIBA-GEIGY AG (CH) 1976-01-06 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11802135-B2 Lysophosphatidic acid derivative LPAR4, LPAR2, LPAR1 ALDH1A1 3134/4885SMN1; SMN2 3474/4885LMNA 1148/4885
US-11718643-B2 Multimodal anion exchange matrices H1-3, H1-4, IGF2R ALDH1A1 2226/4885SMN1; SMN2 3372/4885LMNA 1656/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.