SCHEMBL3059778

SCHEMBL3059778

CCS(=O)(=O)Nc1ccc(C=O)cc1

nearest known ligand 0.66

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
HPGD P15428 9/20 0.66
LMNA P02545 4/20 0.66
HTT P42858 2/20 0.66
SMN1; SMN2 Q16637 2/20 0.66
MAPT P10636 3/20 0.54
L3MBTL1 Q9Y468 1/20 0.54
NR3C2 P08235 1/20 0.50
KIF11 P52732 1/20 0.50
AR P10275 1/20 0.46
ALDH1A1 P00352 2/20 0.44
ALDH3A1 P30838 1/20 0.44
ALDH1A3 P47895 1/20 0.44
KDM4E B2RXH2 1/20 0.42
PGR P06401 1/20 0.42
CYP2A6 P11509 1/20 0.41
BRPF1 P55201 1/20 0.41
TP53 P04637 1/20 0.40
RXFP1 Q9HBX9 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9835864 0.87 HPGD (0.50) HPGDLMNAHTTSMN1; SMN2MAPT
SCHEMBL3063965 0.83 HPGD (0.55) HPGDLMNAHTTSMN1; SMN2MAPT
SCHEMBL3061132 0.82 HPGD (0.44) HPGDLMNAHTTSMN1; SMN2MAPT
SCHEMBL3070158 0.82 GRIA4 (0.47) HPGDLMNAHTTSMN1; SMN2MAPT
SCHEMBL12678665 0.81 HPGD (0.56) HPGDLMNAHTTSMN1; SMN2MAPT
SCHEMBL5332931 0.80 HPGD (0.60) HPGDLMNAHTTSMN1; SMN2MAPT
SCHEMBL394895 0.79 ALDH1A1 (0.61) HPGDLMNAHTTSMN1; SMN2MAPT
SCHEMBL6798952 0.78 PGR (0.46) HPGDLMNAHTTSMN1; SMN2MAPT
SCHEMBL9654379 0.78 HPGD (0.49) HPGDLMNAHTTSMN1; SMN2MAPT
SCHEMBL9054541 0.77 HPGD (0.67) HPGDLMNAHTTSMN1; SMN2MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250066358-A1 Inhibitors of Menin-MLL Interaction BALA THERAPEUTICS, INC. 2025-02-27 US disclosed
EP-4444313-A1 INHIBITORS OF MENIN-MLL INTERACTION Bala Therapeutics, Inc. (US) 2024-10-16 EP disclosed
WO-2023107687-A1 INHIBITORS OF MENIN-MLL INTERACTION BALA THERAPEUTICS, INC. (US) 2023-06-15 WO disclosed
US-8551999-B2 Heterocyclic compound and pharmaceutical composition thereof OTSUKA PHARMACEUTICAL CO., LTD. (JP) 2013-10-08 US disclosed
EP-2207773-B1 HETEROCYCLIC COMPOUND AND PHARMACEUTICAL COMPOSITION THEREOF OTSUKA PHARMA CO LTD (JP) 2012-07-11 EP disclosed
US-20100261720-A1 HETEROCYCLIC COMPOUND AND PHARMACEUTICAL COMPOSITION THEREOF OTSUKA PHARMACEUTICAL CO., LTD. (JP) 2010-10-14 US disclosed
EP-2207773-A2 HETEROCYCLIC COMPOUND AND PHARMACEUTICAL COMPOSITION THEREOF Otsuka Pharmaceutical Co., Ltd. (JP) 2010-07-21 EP disclosed
WO-2009057811-A2 HETEROCYCLIC COMPOUND AND PHARMACEUTICAL COMPOSITION THEREOF OTSUKA PHARMACEUTICAL CO., LTD. (JP) 2009-05-07 WO disclosed
EP-0967517-B1 A dye and silver halide photographic light sensitive material containing a fine solid particle dispersion of said dye KONISHIROKU PHOTO IND (JP) 2004-01-02 EP disclosed
US-6187929-B1 NONDIFFUSIBLE DYE PROVIDING HIGH SPEED SILVER HALIDE PHOTOGRAPHIC LIGHT SENSITIVE MATERIAL WITH REDUCED FOG FORMATION AND IMPROVED STABILITY WITH PASSAGE OF TIME KONICA CORPORATION (JP) 2001-02-13 US disclosed
US-5998117-A METHINE DYE CAPABLE OF BEING DECOLORED BY REACTING WITH A COLOR DEVELOPING AGENT. KONICA CORPORATION (JP) 1999-12-07 US disclosed
EP-0795780-A1 Silver halide photographic light-sensitive material KONICA CORPORATION (JP) 1997-09-17 EP disclosed
EP-0401709-B1 X-ray photographic material FUJI PHOTO FILM CO LTD (JP) 1995-12-27 EP disclosed
US-5147769-A Image sharpness FUJI PHOTO FILM CO., LTD. (JP) 1992-09-15 US disclosed
EP-0215124-B1 SILVER HALIDE PHOTOGRAPHIC PHOTO-SENSITIVE MATERIAL FUJI PHOTO FILM CO., LTD. (JP) 1991-09-04 EP disclosed
US-4925782-A Silver halide photographic light-sensitive element containing water soluble dye compounds FUJI PHOTO FILM CO., LTD. (JP) 1990-05-15 US disclosed
US-4879204-A HIGH CONTRAST FUJI PHOTO FILM CO., LTD. (JP) 1989-11-07 US disclosed
EP-0319999-A2 Silver halide photographic materials Fuji Photo Film Co., Ltd. (JP) 1989-06-14 EP disclosed
US-4764455-A Color image-forming process FUJI PHOTO FILM CO., LTD. (JP) 1988-08-16 US disclosed
EP-0215124-A1 SILVER HALIDE PHOTOGRAPHIC PHOTO-SENSITIVE MATERIAL FUJI PHOTO FILM CO., LTD. (JP) 1987-03-25 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100261720-A1 HETEROCYCLIC COMPOUND AND PHARMACEUTICAL COMPOSITION THEREOF COL1A1, COL2A1, COL14A1 HPGD 263/4885LMNA 1184/4885HTT 1225/4885
US-20250066358-A1 Inhibitors of Menin-MLL Interaction MLLT1, MEN1, BMI1 HPGD 2981/4885LMNA 531/4885HTT 3578/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.