Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | RAB9A | P51151 | 3/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | AHR | P35869 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | BTK | Q06187 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | SGMS2 | Q8NHU3 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.42 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6809507 | 0.80 | SMN1; SMN2 (0.73) | SMN1; SMN2RAB9ANPC1MAPTKMT2A | |
| SCHEMBL3949409 | 0.77 | MRGPRX4 (0.50) | SMN1; SMN2RAB9ANPC1MAPTMEN1 | |
| SCHEMBL20954353 | 0.77 | FFAR1 (0.49) | BTKLMNASGMS2MAOB | |
| SCHEMBL26274009 | 0.74 | LMNA (0.57) | SMN1; SMN2RAB9AMAPTMEN1KMT2A | |
| SCHEMBL26274509 | 0.74 | ALDH1A1 (0.61) | SMN1; SMN2RAB9ANPC1MAPTMEN1 | |
| SCHEMBL3941686 | 0.73 | RAB9A (0.52) | RAB9ANPC1MAPTGAAMCHR1 | |
| SCHEMBL30368222 | 0.72 | ALDH1A1 (0.66) | SMN1; SMN2RAB9ANPC1MAPTMEN1 | |
| SCHEMBL171190 | 0.72 | ALDH1A1 (0.66) | SMN1; SMN2RAB9ANPC1MAPTMEN1 | |
| SCHEMBL13942048 | 0.72 | RAB9A (0.64) | SMN1; SMN2RAB9ANPC1MAPTMEN1 | |
| SCHEMBL10755249 | 0.71 | NPC1 (0.74) | SMN1; SMN2RAB9ANPC1MAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009020457-A2 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-02-12 | — | — | WO | disclosed |