Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA5 | P22460 | 2/20 | 0.45 |
| ▸ | ALOX5AP | P20292 | 10/20 | 0.40 |
| ▸ | FEN1 | P39748 | 10/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.37 |
| ▸ | STAT3 | P40763 | 1/20 | 0.36 |
| ▸ | BDKRB1 | P46663 | 1/20 | 0.36 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.35 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.35 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.34 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18014696 | 0.84 | KIF11 (0.47) | — | |
| SCHEMBL23347204 | 0.81 | ALOX5AP (0.56) | KCNA5ALOX5APFEN1MAOBSTAT3 | |
| SCHEMBL13872997 | 0.81 | PTGS2 (0.43) | KCNA5KCNH2RIPK1PTGS2 | |
| SCHEMBL28936838 | 0.78 | ALOX5AP (0.44) | KCNA5ALOX5APFEN1KCNH2MAOB | |
| SCHEMBL18014704 | 0.77 | CYP2C19 (0.44) | RIPK1PTGS2 | |
| SCHEMBL3756934 | 0.77 | DPP4 (0.57) | KCNA5ALOX5APFEN1MAOB | |
| SCHEMBL22910540 | 0.77 | LTA4H (0.45) | KCNA5ALOX5APFEN1KCNH2STAT3 | |
| SCHEMBL6048497 | 0.77 | SLC6A4 (0.54) | KCNH2 | |
| SCHEMBL5336630 | 0.76 | DPP4 (0.54) | KCNA5KCNH2RIPK1 | |
| Hydrochloric Acid SCHEMBL6048489 | 0.75 | SLC6A4 (0.52) | ALOX5APFEN1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2049484-A1 | ISOINDOLINE DERIVATIVES FOR THE TREATMENT OF ARRHYTHMIAS | AstraZeneca AB (SE) | 2009-04-22 | — | — | EP | disclosed |
| WO-2008008022-A1 | ISOINDOLINE DERIVATIVES FOR THE TREATMENT OF ARRHYTHMIAS | ASTRAZENECA AB (SE) | 2008-01-17 | — | — | WO | disclosed |