Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | THRB | P10828 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8485391 | 0.76 | CNR2 (0.39) | CYP2C19LMNAFFAR3 | |
| SCHEMBL31072057 | 0.74 | NPSR1 (0.34) | KMT2AMEN1 | |
| SCHEMBL8684589 | 0.74 | ANO1 (0.37) | CYP2C19LMNAFFAR3KMT2AMEN1 | |
| SCHEMBL28734388 | 0.74 | LMNA (0.36) | CYP2C19LMNAFFAR3KMT2AMEN1 | |
| SCHEMBL17796127 | 0.73 | MME (0.31) | — | |
| SCHEMBL18793892 | 0.71 | CYP2C9 (0.35) | CYP2C19LMNAFFAR3KMT2AMEN1 | |
| SCHEMBL14920529 | 0.71 | MME (0.33) | CYP2C19LMNA | |
| SCHEMBL8701586 | 0.71 | ALDH1A1 (0.35) | CYP2C19LMNA | |
| SCHEMBL11037700 | 0.71 | ALDH1A1 (0.41) | LMNAKMT2ATHRB | |
| SCHEMBL3093771 | 0.70 | EPHX2 (0.54) | KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2049519-A2 | CYCLIC DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | Brystol-Myers Squibb Company (US) | 2009-04-22 | — | — | EP | disclosed |
| WO-2008014361-A2 | CYCLIC DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | BRISTOL-MYERS SQUIBB COMPANY (US) | 2008-01-31 | — | — | WO | disclosed |