Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR3 | P49019 | 3/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.52 |
| ▸ | MAPT | P10636 | 5/20 | 0.52 |
| ▸ | LMNA | P02545 | 3/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.46 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22495122 | 0.86 | HCAR3 (0.59) | HCAR3ALDH1A1MAPTLMNASMN1; SMN2 | |
| SCHEMBL18262166 | 0.86 | HCAR3 (0.54) | HCAR3ALDH1A1MAPTLMNASMN1; SMN2 | |
| SCHEMBL8672067 | 0.86 | MAPT (0.69) | HCAR3ALDH1A1MAPTLMNASMN1; SMN2 | |
| SCHEMBL18262168 | 0.86 | HCAR3 (0.54) | HCAR3ALDH1A1MAPTLMNASMN1; SMN2 | |
| SCHEMBL4440170 | 0.85 | HCAR3 (0.54) | HCAR3ALDH1A1MAPTLMNASMN1; SMN2 | |
| SCHEMBL4440176 | 0.85 | HCAR3 (0.54) | HCAR3ALDH1A1MAPTLMNASMN1; SMN2 | |
| SCHEMBL3094959 | 0.84 | ALDH1A1 (0.55) | HCAR3ALDH1A1MAPTLMNASMN1; SMN2 | |
| SCHEMBL28905763 | 0.83 | HCAR3 (0.52) | HCAR3ALDH1A1MAPTLMNASMN1; SMN2 | |
| SCHEMBL27910633 | 0.82 | HCAR3 (0.54) | HCAR3ALDH1A1MAPTLMNASMN1; SMN2 | |
| SCHEMBL3992139 | 0.82 | MAPK1 (0.65) | HCAR3ALDH1A1MAPTMAPK1PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1934199-B1 | INDANE DERIVATIVES AS MCH RECEPTOR ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2009-04-22 | — | — | EP | disclosed |