Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR3 | P49019 | 3/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | ALDH3A1 | P30838 | 4/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.51 |
| ▸ | WNK1 | Q9H4A3 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4440170 | 1.00 | HCAR3 (0.54) | HCAR3ALDH1A1ALDH3A1LMNAMEN1 | |
| SCHEMBL27910633 | 0.89 | HCAR3 (0.54) | HCAR3ALDH1A1ALDH3A1LMNAMEN1 | |
| SCHEMBL4445873 | 0.85 | GPR119 (0.54) | ALDH1A1LMNAMAPTPOLBSMN1; SMN2 | |
| SCHEMBL3950396 | 0.85 | HCAR3 (0.57) | HCAR3ALDH1A1ALDH3A1LMNAMEN1 | |
| SCHEMBL22495122 | 0.83 | HCAR3 (0.59) | HCAR3ALDH1A1LMNAWNK1MAPT | |
| SCHEMBL1956333 | 0.82 | MAPT (0.50) | HCAR3ALDH1A1ALDH3A1LMNAMEN1 | |
| SCHEMBL3528454 | 0.82 | ALDH1A1 (0.51) | HCAR3ALDH1A1ALDH3A1LMNAMEN1 | |
| SCHEMBL28073275 | 0.82 | MAPT (0.50) | HCAR3ALDH1A1ALDH3A1LMNAMEN1 | |
| SCHEMBL3528450 | 0.82 | ALDH1A1 (0.51) | HCAR3ALDH1A1ALDH3A1LMNAMEN1 | |
| SCHEMBL28131025 | 0.82 | MAPT (0.50) | HCAR3ALDH1A1ALDH3A1LMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2121656-A1 | INHIBITORS OF SERINE PALMITOYLTRANSFERASE | Pfizer Products Inc. (US) | 2009-11-25 | — | — | EP | disclosed |
| WO-2008084300-A1 | INHIBITORS OF SERINE PALMITOYLTRANSFERASE | PFIZER PRODUCTS INC. (US) | 2008-07-17 | — | — | WO | disclosed |