⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL891845 | 0.73 | — | — | |
| SCHEMBL11365878 | 0.69 | — | — | |
| SCHEMBL891818 | 0.69 | THRB (0.32) | — | |
| SCHEMBL9935879 | 0.69 | — | — | |
| SCHEMBL9935877 | 0.69 | — | — | |
| SCHEMBL2884062 | 0.69 | PKM (0.39) | — | |
| SCHEMBL9935040 | 0.69 | — | — | |
| SCHEMBL4604253 | 0.67 | — | — | |
| SCHEMBL22208158 | 0.67 | ALDH1A1 (0.32) | — | |
| Water SCHEMBL27655125 | 0.67 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 65 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117624129-A | Synthesis method of RAF265 inhibitor | 上海图芃生物科技有限公司 | 2024-03-01 | — | — | CN | claimed |
| CN-118369094-A | Process for preparing substituted pyrazolopyrimidines | KSQ治疗公司 | 2024-07-19 | — | — | CN | disclosed |
| CN-118103362-A | Herbicidal imidazole compounds | 先正达农作物保护股份公司 | 2024-05-28 | — | — | CN | disclosed |
| CN-111132979-B | Benzoxazinone derivatives as herbicides | 瑞戴格作物保护公司 | 2024-03-26 | — | — | CN | disclosed |
| CN-117624129-A | Synthesis method of RAF265 inhibitor | 上海图芃生物科技有限公司 | 2024-03-01 | — | — | CN | disclosed |
| CN-117460718-A | Triazine derivatives and their use in the treatment of cancer | 豪夫迈·罗氏有限公司 | 2024-01-26 | — | — | CN | disclosed |
| CN-117263944-A | Ubiquitin-specific protease 1 inhibitors and uses thereof | 轩竹生物科技股份有限公司 | 2023-12-22 | — | — | CN | disclosed |
| CN-117136189-A | Ubiquitin-specific protease 1 (USP 1) inhibitors | 先声再明医药有限公司 | 2023-11-28 | — | — | CN | disclosed |
| CN-116925098-A | Small molecule inhibitor targeting ubiquitin-specific protease 1 (USP 1) and application thereof | 深圳湾实验室 | 2023-10-24 | — | — | CN | disclosed |
| CN-116813619-A | Macrocyclic inhibitors of Wee1 | 南京正大天晴制药有限公司 | 2023-09-29 | — | — | CN | disclosed |
| US-4853383-A | β-blocking substituted imidazoles | MERCK & CO., INC. (US) | 1989-08-01 | — | — | US | disclosed |
| EP-0229922-A2 | Novel 2,2'-BI-1H-imidazoles | MERRELL DOW PHARMACEUTICALS INC. (US) | 1987-07-29 | — | — | EP | disclosed |
| US-4642311-A | β-adrenergic blocking imidazolylphenoxy propanolamines | MERCK & CO., INC. (US) | 1987-02-10 | — | — | US | disclosed |
| US-4567276-A | HYPOTENSIVE AGENTS, ADRENERGIC BLOCKING AGENTS | MERCK & CO., INC. (US) | 1986-01-28 | — | — | US | disclosed |
| US-4559354-A | ADRENERGIC BLOCKING AGENTS AND STIMULANTS; CARDIOTONIC, ANTIARRHYTHMIA AND INOTROPIC AGENTS | CIBA-GEIGY CORPORATION (US) | 1985-12-17 | — | — | US | disclosed |
| US-4440774-A | ANTIHYPERTENSIVE AGENTS AND B-ANDRENERGIC BLOCKING AGENTS | MERCK & CO., INC. (US) | 1984-04-03 | — | — | US | disclosed |
| US-4199580-A | HYPOTENSIVE AGENTS AND ADRENERGIC BLOCKING AGENTS | MERCK & CO., INC. (US) | 1980-04-22 | — | — | US | disclosed |
| US-4134983-A | HYPOTENSIVE, ADRENERGIC BLOCKING AGENTS | MERCK & CO., INC. (US) | 1979-01-16 | — | — | US | disclosed |
| US-4125530-A | FROM 1,1-DIHALO-3,3,3-TRIFLUOROACETONE, BASE, AMMONIA AND A CARBOXALDEHYDE | MERCK & CO., INC. (US) | 1978-11-14 | — | — | US | disclosed |
| US-4032522-A | ANTI-GOUT, ANTI-HYPERURICEMIC | MERCK & CO., INC. (US) | 1977-06-28 | — | — | US | disclosed |