Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASR | P41180 | 5/20 | 0.35 |
| ▸ | PDK1 | Q15118 | 3/20 | 0.35 |
| ▸ | CNR1 | P21554 | 1/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.34 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.33 |
| ▸ | BACE1 | P56817 | 3/20 | 0.33 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.33 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.33 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.33 |
| ▸ | ABHD6 | Q9BV23 | 1/20 | 0.33 |
| ▸ | PPARG | P37231 | 1/20 | 0.32 |
| ▸ | CDK1 | P06493 | 1/20 | 0.32 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.32 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.32 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3947316 | 0.90 | CASR (0.41) | CASRPDK1CNR1ALOX5SLC16A3 | |
| SCHEMBL3946482 | 0.87 | ALOX5 (0.39) | PDK1ALOX5SLC16A3MEN1LMNA | |
| SCHEMBL3952000 | 0.82 | SLC16A3 (0.40) | CASRPDK1ALOX5SLC16A3MEN1 | |
| SCHEMBL3948201 | 0.82 | SLC6A2 (0.37) | CASRPDK1ALOX5SLC16A3MEN1 | |
| SCHEMBL3946983 | 0.81 | CASR (0.43) | CASRPDK1CNR1MEN1KMT2A | |
| SCHEMBL3942446 | 0.81 | CASR (0.41) | CASRPDK1CNR1ALOX5BACE1 | |
| SCHEMBL3943392 | 0.81 | ITGB1 (0.38) | CASRPDK1ALOX5BACE1 | |
| SCHEMBL3951654 | 0.81 | CASR (0.41) | CASRCNR1BACE1MEN1KMT2A | |
| SCHEMBL3945373 | 0.80 | CASR (0.37) | CASRPDK1ALOX5BACE1MEN1 | |
| SCHEMBL3945206 | 0.80 | CASR (0.37) | CASRPDK1ALOX5BACE1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1718632-B1 | PYRIMIDINE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS | SANOFI AVENTIS (FR) | 2009-04-22 | — | — | EP | claimed |