Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 2/20 | 0.37 |
| ▸ | CACNA2D1 | P54289 | 2/20 | 0.37 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.35 |
| ▸ | SYK | P43405 | 2/20 | 0.34 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.34 |
| ▸ | INCENP | Q9NQS7 | 2/20 | 0.34 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.33 |
| ▸ | CASR | P41180 | 3/20 | 0.33 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.33 |
| ▸ | PTGFR | P43088 | 1/20 | 0.32 |
| ▸ | GBA1 | P04062 | 1/20 | 0.32 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.32 |
| ▸ | TCF7L2 | Q9NQB0 | 1/20 | 0.32 |
| ▸ | PDE5A | O76074 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3947316 | 0.90 | CASR (0.41) | ALOX5MKNK1CASRPDK1SLC16A3 | |
| SCHEMBL3946482 | 0.87 | ALOX5 (0.39) | ALOX5MKNK1PDK1SLC16A3MEN1 | |
| SCHEMBL3946983 | 0.82 | CASR (0.43) | CASRPDK1MEN1KMT2A | |
| SCHEMBL3942446 | 0.82 | CASR (0.41) | ALOX5CASRPDK1LMNA | |
| SCHEMBL3953649 | 0.82 | CASR (0.35) | ALOX5CASRPDK1SLC16A3MEN1 | |
| SCHEMBL3943392 | 0.82 | ITGB1 (0.38) | ALOX5MKNK1CASRPDK1 | |
| SCHEMBL3951654 | 0.81 | CASR (0.41) | CASRMEN1KMT2A | |
| SCHEMBL3945206 | 0.81 | CASR (0.37) | SLC6A2CACNA2D1ALOX5MKNK1CASR | |
| SCHEMBL3945373 | 0.81 | CASR (0.37) | SLC6A2CACNA2D1ALOX5MKNK1CASR | |
| SCHEMBL3951648 | 0.81 | TSPO (0.37) | ALOX5MKNK1CASRPDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1718632-B1 | PYRIMIDINE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS | SANOFI AVENTIS (FR) | 2009-04-22 | — | — | EP | claimed |