Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PYCR1 | P32322 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL103813 | 0.66 | MAPK14 (0.40) | PYCR1ALDH1A1HPGD | |
| SCHEMBL103397 | 0.65 | MAPK14 (0.38) | PYCR1ALDH1A1 | |
| SCHEMBL103796 | 0.63 | CREBBP (0.46) | PYCR1ALDH1A1 | |
| SCHEMBL102272 | 0.62 | PTGS2 (0.51) | — | |
| SCHEMBL104366 | 0.60 | KDM5A (0.35) | PYCR1ALDH1A1HPGD | |
| SCHEMBL396009 | 0.60 | SCN4A (0.45) | ALDH1A1HPGD | |
| SCHEMBL102255 | 0.60 | MET (0.36) | PYCR1ALDH1A1 | |
| SCHEMBL25667133 | 0.57 | ACHE (0.43) | ALDH1A1HPGD | |
| SCHEMBL103535 | 0.56 | NPC1 (0.35) | — | |
| SCHEMBL1311590 | 0.55 | TAAR1 (0.50) | PYCR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8101637-B2 | Alkynyl derivatives as modulators of metatropic glutamate receptors | ADDEX PHARMA SA (CH) | 2012-01-24 | — | — | US | disclosed |
| US-20090124625-A1 | NOVEL ALKYNYL DERIVATIVES AS MODULATORS OF METATROPIC GLUTAMATE RECEPTORS | ADDEX PHARMACEUTICALS SA (CH) | 2009-05-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090124625-A1 | NOVEL ALKYNYL DERIVATIVES AS MODULATORS OF METATROPIC GLUTAMATE RECEPTORS | GRM5, GRM2, GRM1 | PYCR1 1595/4885ALDH1A1 2496/4885HPGD 3146/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.