Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT1 | Q96EB6 | 5/20 | 0.42 |
| ▸ | SIRT2 | Q8IXJ6 | 4/20 | 0.37 |
| ▸ | SIRT3 | Q9NTG7 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 7/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 5/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.34 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.34 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.34 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.34 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.34 |
| ▸ | HDAC9 | Q9UKV0 | 3/20 | 0.34 |
| ▸ | HDAC5 | Q9UQL6 | 3/20 | 0.34 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.32 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4052446 | 0.84 | MAPT (0.47) | MAPTNPSR1 | |
| SCHEMBL4048878 | 0.82 | HDAC1 (0.33) | HDAC6HDAC1HDAC3HDAC2HDAC8 | |
| SCHEMBL5469798 | 0.81 | HDAC6 (0.52) | HDAC6HDAC1HDAC3HDAC2HDAC8 | |
| SCHEMBL5461533 | 0.76 | HDAC6 (0.44) | HDAC6HDAC1HDAC3HDAC2HDAC8 | |
| SCHEMBL393077 | 0.75 | F11 (0.40) | — | |
| SCHEMBL5355871 | 0.73 | HDAC1 (0.39) | MAPTHDAC6HDAC1ALOX15HSD17B10 | |
| SCHEMBL5466807 | 0.73 | HDAC6 (0.43) | HDAC6HDAC1HDAC3HDAC2HDAC8 | |
| SCHEMBL5363436 | 0.73 | HDAC6 (0.55) | HDAC6HDAC1HDAC3HDAC2HDAC8 | |
| SCHEMBL4049526 | 0.71 | ADORA3 (0.38) | HDAC6HDAC1ADORA3 | |
| SCHEMBL4050458 | 0.71 | CYP1A2 (0.41) | HDAC6HDAC1HDAC3HDAC2HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009026701-A1 | SIRTUIN INHIBITORS | METHYLGENE INC. (CA) | 2009-03-05 | — | — | WO | disclosed |