Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 6/20 | 0.42 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.38 |
| ▸ | GNAI3 | P08754 | 1/20 | 0.38 |
| ▸ | GNAO1 | P09471 | 1/20 | 0.38 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.38 |
| ▸ | QDPR | P09417 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3457863 | 0.90 | EPHX2 (0.39) | EPHX2EPHX1CYP1A2TDP1GNAI3 | |
| SCHEMBL771884 | 0.85 | EPHX2 (0.43) | EPHX2EPHX1CYP1A2TDP1KDM4E | |
| SCHEMBL12641 | 0.83 | GNAI3 (0.45) | EPHX2EPHX1CYP1A2TDP1KDM4E | |
| SCHEMBL1501881 | 0.83 | AKR1C3 (0.43) | EPHX2EPHX1CYP1A2TDP1KDM4E | |
| SCHEMBL3122925 | 0.82 | EPHX2 (0.41) | EPHX2EPHX1CYP1A2TDP1KDM4E | |
| SCHEMBL13804037 | 0.82 | ALDH1A1 (0.42) | EPHX2EPHX1CYP1A2TDP1GNAI3 | |
| SCHEMBL6043115 | 0.82 | CHRM2 (0.44) | EPHX2EPHX1CYP1A2TDP1KDM4E | |
| SCHEMBL4569262 | 0.80 | EPHX2 (0.43) | EPHX2EPHX1CYP1A2TDP1KDM4E | |
| SCHEMBL3036073 | 0.80 | ITGB3 (0.46) | EPHX2EPHX1GNAI3GNAO1GNAI1 | |
| SCHEMBL7299175 | 0.80 | AKR1C3 (0.45) | EPHX2EPHX1CYP1A2TDP1GNAI3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009024825-A1 | 2-PYRAZINYLBENZIMIDAZOLE DERIVATIVES AS RECEPTOR TYROSINE KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2009-02-26 | — | — | WO | disclosed |
| US-5488140-A | ANTICONVULSANTS | CIBA-GEIGY CORPORATION (US) | 1996-01-30 | — | — | US | disclosed |
| EP-0420806-B1 | Phosphonic acids, process for preparation and use as an active pharmaceutical composition | CIBA GEIGY AG (CH) | 1995-07-05 | — | — | EP | disclosed |
| US-5294734-A | 1-phosphato-4-amino-pent-2-enoic acids and derivatives | CIBA-GEIGY CORP. (US) | 1994-03-15 | — | — | US | disclosed |
| EP-0420806-A1 | Phosphonic acids, process for preparation and use as an active pharmaceutical composition | CIBA-GEIGY AG (CH) | 1991-04-03 | — | — | EP | disclosed |