Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GNAO1 | P09471 | 3/20 | 0.41 |
| ▸ | DRD2 | P14416 | 5/20 | 0.39 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.36 |
| ▸ | GNAI3 | P08754 | 2/20 | 0.36 |
| ▸ | GNAI1 | P63096 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.35 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.35 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.35 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.35 |
| ▸ | DRD4 | P21917 | 2/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.35 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.35 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3947070 | 0.89 | GNAO1 (0.43) | GNAO1DRD2EPHX1EPHX2HTR4 | |
| SCHEMBL3950352 | 0.85 | SMN1; SMN2 (0.41) | GNAO1EPHX1EPHX2HTR4SMN1; SMN2 | |
| SCHEMBL3956282 | 0.81 | SLC18A3 (0.39) | DRD2SMN1; SMN2HRH3CHRM1CHRM2 | |
| SCHEMBL7290102 | 0.81 | GNAO1 (0.49) | GNAO1DRD2EPHX1EPHX2HTR4 | |
| SCHEMBL3947113 | 0.81 | GNAO1 (0.47) | GNAO1DRD2EPHX1EPHX2HTR4 | |
| SCHEMBL3948879 | 0.80 | NCF1 (0.46) | GNAO1HTR4GNAI3GNAI1HRH3 | |
| SCHEMBL7741719 | 0.80 | GNAO1 (0.49) | GNAO1DRD2EPHX1EPHX2GNAI3 | |
| SCHEMBL3950912 | 0.79 | CHRM1 (0.40) | GNAO1DRD2HRH3CHRM1CHRM2 | |
| SCHEMBL3948738 | 0.79 | GNAO1 (0.45) | GNAO1DRD2EPHX1EPHX2HTR4 | |
| SCHEMBL3955898 | 0.78 | GNAO1 (0.48) | GNAO1DRD2EPHX1EPHX2GNAI3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009024825-A1 | 2-PYRAZINYLBENZIMIDAZOLE DERIVATIVES AS RECEPTOR TYROSINE KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2009-02-26 | — | — | WO | disclosed |