Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.41 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.40 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.35 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.34 |
| ▸ | GNAO1 | P09471 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.32 |
| ▸ | MAOA | P21397 | 1/20 | 0.31 |
| ▸ | MAOB | P27338 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3947872 | 0.89 | SMN1; SMN2 (0.39) | SMN1; SMN2HRH3HSD11B1EPHX1EPHX2 | |
| SCHEMBL3956166 | 0.85 | GNAO1 (0.41) | SMN1; SMN2HRH3EPHX1EPHX2HTR4 | |
| SCHEMBL31273888 | 0.80 | HRH3 (0.49) | SMN1; SMN2HRH3HSD11B1EPHX1EPHX2 | |
| SCHEMBL3947858 | 0.79 | EPHX1 (0.40) | SMN1; SMN2HRH3HSD11B1EPHX1EPHX2 | |
| SCHEMBL3948879 | 0.79 | NCF1 (0.46) | HRH3HTR4GNAO1ALDH1A1 | |
| SCHEMBL3956282 | 0.77 | SLC18A3 (0.39) | SMN1; SMN2HRH3HSD11B1ALDH1A1CHRM4 | |
| SCHEMBL4383559 | 0.77 | SMN1; SMN2 (0.45) | SMN1; SMN2HRH3HSD11B1EPHX1EPHX2 | |
| SCHEMBL3955899 | 0.77 | SMN1; SMN2 (0.45) | SMN1; SMN2HRH3HSD11B1EPHX1EPHX2 | |
| SCHEMBL4045148 | 0.77 | ADH1B (0.42) | SMN1; SMN2HRH3HSD11B1EPHX1EPHX2 | |
| SCHEMBL31273045 | 0.76 | HRH3 (0.46) | SMN1; SMN2HRH3HSD11B1EPHX1EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009024825-A1 | 2-PYRAZINYLBENZIMIDAZOLE DERIVATIVES AS RECEPTOR TYROSINE KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2009-02-26 | — | — | WO | disclosed |