Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GNAO1 | P09471 | 5/20 | 0.48 |
| ▸ | GNAI3 | P08754 | 4/20 | 0.48 |
| ▸ | GNAI1 | P63096 | 4/20 | 0.48 |
| ▸ | ADH1B | P00325 | 3/20 | 0.44 |
| ▸ | ADH1A | P07327 | 3/20 | 0.44 |
| ▸ | ADH7 | P40394 | 3/20 | 0.44 |
| ▸ | ADH1C | P00326 | 2/20 | 0.44 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.43 |
| ▸ | ADH4 | P08319 | 1/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 5/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 4/20 | 0.37 |
| ▸ | CHRM4 | P08173 | 4/20 | 0.37 |
| ▸ | CHRM5 | P08912 | 4/20 | 0.37 |
| ▸ | CHRM3 | P20309 | 4/20 | 0.37 |
| ▸ | DRD2 | P14416 | 3/20 | 0.37 |
| ▸ | DRD4 | P21917 | 3/20 | 0.37 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.37 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3947113 | 0.90 | GNAO1 (0.47) | GNAO1GNAI3GNAI1ADH1BADH1A | |
| SCHEMBL4045148 | 0.87 | ADH1B (0.42) | GNAO1GNAI3GNAI1ADH1BADH1A | |
| SCHEMBL3949738 | 0.84 | GNAI3 (0.42) | GNAO1GNAI3GNAI1CHRM1CHRM2 | |
| SCHEMBL3950651 | 0.83 | GNAI3 (0.41) | GNAO1GNAI3GNAI1CHRM1CHRM2 | |
| SCHEMBL3947070 | 0.82 | GNAO1 (0.43) | GNAO1GNAI3GNAI1EPHX1CHRM1 | |
| SCHEMBL3950841 | 0.81 | ALDH1A1 (0.39) | GNAO1GNAI3GNAI1CHRM1CHRM2 | |
| SCHEMBL3949394 | 0.81 | ALDH1A1 (0.41) | GNAO1GNAI3GNAI1EPHX1CHRM1 | |
| SCHEMBL3950791 | 0.80 | ADH1B (0.54) | GNAO1GNAI3GNAI1ADH1BADH1A | |
| SCHEMBL31273549 | 0.79 | GNAO1 (0.51) | GNAO1GNAI3GNAI1CHRM1CHRM2 | |
| SCHEMBL31273564 | 0.79 | GNAO1 (0.51) | GNAO1GNAI3GNAI1CHRM1CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009024825-A1 | 2-PYRAZINYLBENZIMIDAZOLE DERIVATIVES AS RECEPTOR TYROSINE KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2009-02-26 | — | — | WO | disclosed |