Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.50 |
| ▸ | FBP1 | P09467 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | AKR1C3 | P42330 | 5/20 | 0.46 |
| ▸ | AKR1C4 | P17516 | 4/20 | 0.46 |
| ▸ | AKR1C2 | P52895 | 4/20 | 0.46 |
| ▸ | AKR1C1 | Q04828 | 4/20 | 0.46 |
| ▸ | AR | P10275 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.43 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | RHOA | P61586 | 1/20 | 0.43 |
| ▸ | MYC | P01106 | 1/20 | 0.43 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3956332 | 1.00 | MAPT (0.50) | MAPTNPC1RAB9APKMPAX8 | |
| SCHEMBL3956355 | 0.77 | KMT2A (0.53) | MAPTNPC1RAB9AFBP1POLB | |
| SCHEMBL3956358 | 0.77 | KMT2A (0.53) | MAPTNPC1RAB9AFBP1POLB | |
| SCHEMBL3953898 | 0.76 | AKR1C3 (0.45) | MAPTNPC1RAB9APKMAKR1C3 | |
| SCHEMBL6651219 | 0.76 | AKR1C3 (0.45) | MAPTNPC1RAB9APKMAKR1C3 | |
| SCHEMBL3957248 | 0.75 | FBP1 (0.50) | MAPTFBP1MEN1KMT2A | |
| SCHEMBL3956338 | 0.75 | FBP1 (0.57) | MAPTNPC1RAB9APKMPAX8 | |
| SCHEMBL3957246 | 0.75 | FBP1 (0.50) | MAPTFBP1MEN1KMT2A | |
| SCHEMBL28211098 | 0.74 | MAPT (0.57) | MAPTNPC1RAB9APKMPAX8 | |
| SCHEMBL2444355 | 0.74 | AKR1C3 (0.53) | MAPTNPC1RAB9APKMAKR1C3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7560473-B2 | Amine derivative with potassium channel regulatory function, its preparation and use | INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY ACADEMY OF MILITARY MEDICAL SCIENCES, P.L.A. (CN) | 2009-07-14 | — | — | US | disclosed |
| US-20040266822-A1 | Amine derivative with potassium channel regulatory function, its preparation and use | INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY ACADEMY OF MILITARY MEDICAL SCIENCES P.L.A. (CN) | 2004-12-30 | — | — | US | disclosed |
| EP-1386908-A1 | AMINE DERIVATIVE WITH POTASSIUM CHANNEL REGULATORY FUNCTION, ITS PREPARATION AND USE | Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.L.A. (CN) | 2004-02-04 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040266822-A1 | Amine derivative with potassium channel regulatory function, its preparation and use | KCNMA1, KCNA5, KCNA1 | MAPT 2941/4885NPC1 3722/4885RAB9A 2137/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.