Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 2/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.56 |
| ▸ | NPC1 | O15118 | 1/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 6/20 | 0.54 |
| ▸ | ATM | Q13315 | 1/20 | 0.54 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | RAF1 | P04049 | 6/20 | 0.52 |
| ▸ | BRAF | P15056 | 6/20 | 0.52 |
| ▸ | RARB | P10826 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | RPS6KA2 | Q15349 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3955448 | 0.94 | RAB9A (0.56) | PKMMAPK1NPC1TP53RAB9A | |
| SCHEMBL2345369 | 0.83 | RARB (0.66) | PKMMAPK1NPC1TP53RAB9A | |
| SCHEMBL3962780 | 0.82 | MAPT (0.54) | PKMMAPK1NPC1TP53RAB9A | |
| SCHEMBL4245782 | 0.80 | SMN1; SMN2 (0.54) | PKMMAPK1NPC1TP53RAB9A | |
| SCHEMBL12459071 | 0.79 | NPC1 (0.74) | PKMMAPK1NPC1TP53RAB9A | |
| SCHEMBL2913173 | 0.79 | PKM (0.65) | PKMMAPK1NPC1TP53RAB9A | |
| SCHEMBL2346857 | 0.78 | MAPT (0.64) | PKMMAPK1NPC1TP53RAB9A | |
| SCHEMBL2352480 | 0.77 | PKM (0.70) | PKMMAPK1NPC1TP53RAB9A | |
| SCHEMBL3958957 | 0.76 | MAPT (0.47) | PKMMAPK1NPC1TP53RAB9A | |
| SCHEMBL2346560 | 0.76 | RARA (0.66) | PKMMAPK1NPC1TP53RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009034390-A1 | HETEROCYCLIC DERIVATIVES AND THEIR USE IN TREATING HEPATITIS C | ARROW THERAPEUTICS LIMITED (GB) | 2009-03-19 | — | — | WO | disclosed |