Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 10/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.52 |
| ▸ | WNT3A | P56704 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.48 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.48 |
| ▸ | JAK2 | O60674 | 1/20 | 0.47 |
| ▸ | JAK1 | P23458 | 1/20 | 0.47 |
| ▸ | TYK2 | P29597 | 1/20 | 0.47 |
| ▸ | JAK3 | P52333 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4235980 | 0.88 | MAPT (0.52) | SMN1; SMN2MAPTL3MBTL1WNT3AMAPK1 | |
| SCHEMBL3955448 | 0.82 | RAB9A (0.56) | SMN1; SMN2MAPTMAPK1NPC1TP53 | |
| SCHEMBL3959399 | 0.80 | PKM (0.56) | SMN1; SMN2MAPTMAPK1NPC1TP53 | |
| SCHEMBL4237879 | 0.79 | SMN1; SMN2 (0.55) | SMN1; SMN2MAPTL3MBTL1CYP1A2CYP3A4 | |
| SCHEMBL2913173 | 0.72 | PKM (0.65) | SMN1; SMN2MAPTMAPK1NPC1TP53 | |
| SCHEMBL2346560 | 0.72 | RARA (0.66) | SMN1; SMN2MAPTMAPK1NPC1TP53 | |
| SCHEMBL4890453 | 0.72 | MAPT (0.60) | MAPTMAPK1NPC1RAB9AMAPKAPK2 | |
| SCHEMBL4562679 | 0.71 | MAPT (0.59) | SMN1; SMN2MAPTL3MBTL1CYP1A2CYP3A4 | |
| SCHEMBL3962780 | 0.71 | MAPT (0.54) | SMN1; SMN2MAPTL3MBTL1MAPK1NPC1 | |
| SCHEMBL2352480 | 0.70 | PKM (0.70) | SMN1; SMN2MAPTMAPK1NPC1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009034390-A1 | HETEROCYCLIC DERIVATIVES AND THEIR USE IN TREATING HEPATITIS C | ARROW THERAPEUTICS LIMITED (GB) | 2009-03-19 | — | — | WO | disclosed |