Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | XBP1 | P17861 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.44 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.44 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.44 |
| ▸ | TMPRSS4 | Q9NRS4 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27437607 | 0.79 | ALDH1A1 (0.52) | ALDH1A1SMN1; SMN2KDM4EPOLBPKM | |
| SCHEMBL10807183 | 0.78 | ALDH1A1 (0.48) | ALDH1A1SMN1; SMN2KDM4EPOLBPKM | |
| SCHEMBL10757128 | 0.78 | ALDH1A1 (0.57) | ALDH1A1SMN1; SMN2KDM4EPOLBPKM | |
| SCHEMBL11558383 | 0.77 | ALDH1A1 (0.56) | ALDH1A1SMN1; SMN2KDM4EPOLBPKM | |
| SCHEMBL6177056 | 0.77 | ALDH1A1 (0.49) | ALDH1A1SMN1; SMN2KDM4EPOLBPKM | |
| SCHEMBL6175342 | 0.76 | ALDH1A1 (0.64) | ALDH1A1SMN1; SMN2KDM4EPOLBPKM | |
| SCHEMBL10963741 | 0.75 | ALDH1A1 (0.55) | ALDH1A1SMN1; SMN2KDM4EPOLBPKM | |
| SCHEMBL10585717 | 0.75 | ALDH1A1 (0.48) | ALDH1A1SMN1; SMN2KDM4EPOLBPKM | |
| SCHEMBL6176174 | 0.75 | ALDH1A1 (0.57) | ALDH1A1SMN1; SMN2KDM4EPOLBPKM | |
| SCHEMBL11077845 | 0.74 | ALDH1A1 (0.54) | ALDH1A1SMN1; SMN2KDM4EPOLBPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090076268-A1 | Facile assembly of fused benzofuro-heterocycles | JANSSEN PHARMACEUTICA N.V. (BE) | 2009-03-19 | — | — | US | disclosed |
| US-20090076268-A1 | Facile assembly of fused benzofuro-heterocycles | JANSSEN PHARMACEUTICA N.V. (BE) | 2009-03-19 | — | — | US | disclosed |
| US-20090076268-A1 | Facile assembly of fused benzofuro-heterocycles | JANSSEN PHARMACEUTICA N.V. (BE) | 2009-03-19 | — | — | US | disclosed |
| WO-2009035668-A1 | FACILE ASSEMBLY OF FUSED BENZOFURO-HETEROCYCLES | JANSSEN PHARMACEUTICA N.V. (BE) | 2009-03-19 | — | — | WO | disclosed |
| WO-2009035668-A1 | FACILE ASSEMBLY OF FUSED BENZOFURO-HETEROCYCLES | JANSSEN PHARMACEUTICA N.V. (BE) | 2009-03-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090076268-A1 | Facile assembly of fused benzofuro-heterocycles | BICRA, DDC, DDT | ALDH1A1 739/4885SMN1; SMN2 3741/4885KDM4E 1620/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.