Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 6/20 | 0.53 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.53 |
| ▸ | SCN5A | Q14524 | 5/20 | 0.53 |
| ▸ | MDM2 | Q00987 | 4/20 | 0.46 |
| ▸ | TP53 | P04637 | 3/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | CRHBP | P24387 | 1/20 | 0.39 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.39 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.39 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.39 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3954661 | 0.70 | MDM2 (0.42) | SCN9AKCNH2SCN5AMDM2TP53 | |
| SCHEMBL3281023 | 0.67 | MDM2 (0.48) | SCN9AKCNH2SCN5AMDM2TP53 | |
| SCHEMBL13407483 | 0.67 | MDM2 (0.51) | SCN9AKCNH2SCN5AMDM2TP53 | |
| SCHEMBL3889879 | 0.67 | SCN9A (1.00) | SCN9AKCNH2SCN5AKCNQ2KCNA5 | |
| SCHEMBL13389777 | 0.66 | ACHE (0.46) | SCN9AKCNH2SCN5AMDM2TP53 | |
| SCHEMBL20450742 | 0.65 | PDE10A (0.47) | SCN9AKCNH2SCN5AMDM2TP53 | |
| SCHEMBL3288672 | 0.65 | TP53 (0.51) | SCN9AKCNH2SCN5AMDM2TP53 | |
| SCHEMBL5781106 | 0.64 | ALDH1A1 (0.53) | KMT2AMEN1ALDH1A1CYP3A4TDP1 | |
| SCHEMBL28865712 | 0.64 | ALDH1A1 (0.55) | SCN9AMDM2TP53KMT2AMEN1 | |
| SCHEMBL10584591 | 0.64 | MEN1 (0.56) | TP53HSD17B10KMT2AMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009145718-A1 | ISOINDOLINE DERIVATIVES COMPRISING AN ADDITIONAL HETEROCYCLIC GROUP AND THEIR USE IN THE TREATMENT OF PAIN DISORDERS | ASTRAZENECA AB (SE) | 2009-12-03 | — | — | WO | claimed |