Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6701258 | 0.85 | TSHR (0.39) | TSHRGAARECQLKDM4ELMNA | |
| SCHEMBL98369 | 0.85 | SIGMAR1 (0.42) | TSHRGAA | |
| SCHEMBL4870534 | 0.83 | SIGMAR1 (0.45) | TSHRGAALMNA | |
| SCHEMBL1080792 | 0.80 | GAA (0.33) | TSHRGAARECQLKDM4ELMNA | |
| SCHEMBL10430410 | 0.78 | TSHR (0.36) | TSHRGAARECQLKDM4ELMNA | |
| SCHEMBL10621109 | 0.78 | TSHR (0.36) | TSHRGAARECQLKDM4ELMNA | |
| SCHEMBL16749055 | 0.78 | GAA (0.43) | TSHRGAARECQLKDM4ELMNA | |
| SCHEMBL818726 | 0.78 | TSHR (0.36) | TSHRGAARECQLKDM4ELMNA | |
| SCHEMBL21256556 | 0.77 | ALPL (0.31) | — | |
| SCHEMBL10952050 | 0.76 | TSHR (0.36) | TSHRGAARECQLKDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0172413-A2 | Process for producing piperidine derivatives | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1986-02-26 | — | — | EP | claimed |
| CN-111253368-B | Stable nitroxide radical modified naphthalimide compound and application thereof | 沈阳药科大学 | 2020-12-25 | — | — | CN | disclosed |
| CN-101309918-B | [4-(benzo[b]thiophen-2-yl)-pyrimidin-2-yl]-amine derivatives as ikk-beta inhibitors for the treatment of cancer and inflammatory diseases | LILLY CO ELI | 2010-12-29 | — | — | CN | disclosed |
| EP-1989200-B1 | [4-(BENZO[B]THIOPHEN-2-YL)-PYRIMIDIN-2-YL]-AMINE DERIVATIVES AS IKK-BETA INHIBITORS FOR THE TREATMENT OF CANCER AND INFLAMMATORY DISEASES | LILLY CO ELI (US) | 2009-07-29 | — | — | EP | disclosed |
| US-7547691-B2 | [4-(Benzo[B]thiophen-2-yl) Pyrimidin-2-yl]-amine derivatives as IKK-beta inhibitors for the treatment of cancer and inflammatory diseases | ELI LILLY AND COMPANY (US) | 2009-06-16 | — | — | US | disclosed |
| US-20080306082-A1 | [4-(Benzo[B]Thiophen-2-Yl) Pyrimidin-2-Yl]-Amine Derivatives As Ikk-Beta Inhibitors For The Treatment Of Cancer And Inflammatory Diseases | ELI LILLY AND COMPANY | 2008-12-11 | — | — | US | disclosed |
| CN-101309918-A | [4-(benzo[b]thiophen-2-yl)-pyrimidin-2-yl]-amine derivatives as ikk-beta inhibitors for the treatment of cancer and inflammatory diseases | LILLY CO ELI (US) | 2008-11-19 | — | — | CN | disclosed |
| EP-1989200-A2 | [4-(BENZO[B]THIOPHEN-2-YL)-PYRIMIDIN-2-YL]-AMINE DERIVATIVES AS IKK-BETA INHIBITORS FOR THE TREATMENT OF CANCER AND INFLAMMATORY DISEASES | ELI LILLY AND COMPANY (US) | 2008-11-12 | — | — | EP | disclosed |
| WO-2007092095-A2 | [4-(BENZO [B] THI0PHEN-2-YL) PYRIMIDIN-2YL] -AMINE DERIVATIVES AS IKK-BETA INHIBITORS FOR THE TREATMENT OF CANCER AND INFLAMMATORY DISEASES. | ELI LILLY AND COMPANY (US) | 2007-08-16 | — | — | WO | disclosed |
| US-5049604-A | Heat, oxidation and light resistance | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1991-09-17 | — | — | US | disclosed |
| US-4731393-A | TRIAZINYL DERIVATIVES OF PIPERIDINE | CIBA-GEIGY CORPORATION (US) | 1988-03-15 | — | — | US | disclosed |
| EP-0172413-A2 | Process for producing piperidine derivatives | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1986-02-26 | — | — | EP | disclosed |
| US-4481315-A | LACQUERS | CIBA-GEIGY CORPORATION (US) | 1984-11-06 | — | — | US | disclosed |
| EP-0101411-A2 | Process for the chemical bond between a stabilising compound and a polymer | CIBA-GEIGY AG (CH) | 1984-02-22 | — | — | EP | disclosed |
| EP-0010516-B1 | POLYALKYLPIPERIDINE DERIVATIVES, THEIR APPLICATION AS LIGHT STABILISERS AND POLYMERS STABILISED THEREWITH | CIBA-GEIGY AG (CH) | 1982-07-14 | — | — | EP | disclosed |
| US-4289686-A | FOR LACQUERS | CIBA-GEIGY CORPORATION (US) | 1981-09-15 | — | — | US | disclosed |
| US-4286014-A | CHAIN EXTENDER COMPRISING HYDRAZINE OR DERIVATIVE | TORAY INDUSTRIES, INCORPORATED (JP) | 1981-08-25 | — | — | US | disclosed |
| US-4234707-A | Polymeric light stabilizers for plastics | CIBA-GEIGY CORPORATION (US) | 1980-11-18 | — | — | US | disclosed |
| US-4028334-A | STABILIZERS FOR POLYMERS | CIBA-GEIGY CORPORATION (US) | 1977-06-07 | — | — | US | disclosed |
| US-3937711-A | POLYMERIC STABILIZERS, POLYOLEFINS | CIBA-GEIGY CORPORATION (US) | 1976-02-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080306082-A1 | [4-(Benzo[B]Thiophen-2-Yl) Pyrimidin-2-Yl]-Amine Derivatives As Ikk-Beta Inhibitors For The Treatment Of Cancer And Inflammatory Diseases | NFKBIA, IKBKB, IKBKG | TSHR 4012/4885GAA 3041/4885RECQL 3711/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.