Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.48 |
| ▸ | PRNP | P04156 | 1/20 | 0.48 |
| ▸ | PPARG | P37231 | 1/20 | 0.48 |
| ▸ | NR2E3 | Q9Y5X4 | 1/20 | 0.48 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | CASP3 | P42574 | 4/20 | 0.43 |
| ▸ | DPP4 | P27487 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | DHODH | Q02127 | 2/20 | 0.40 |
| ▸ | AURKA | O14965 | 2/20 | 0.40 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.39 |
| ▸ | PTGFR | P43088 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3970472 | 0.82 | RXFP1 (0.47) | RXFP1PRNPPPARGNR2E3NCOR2 | |
| SCHEMBL3969545 | 0.80 | RXFP1 (0.45) | RXFP1PRNPPPARGNR2E3NCOR2 | |
| SCHEMBL3962968 | 0.79 | IDO1 (0.42) | ALDH1A1DPP4KDM4ELMNAPRKAA2 | |
| SCHEMBL3970478 | 0.78 | KDM4E (0.47) | ALDH1A1KDM4E | |
| SCHEMBL13881531 | 0.78 | RXFP1 (0.60) | RXFP1PRNPPPARGNR2E3NCOR2 | |
| SCHEMBL3970605 | 0.78 | PRNP (0.79) | RXFP1PRNPPPARGNR2E3NCOR2 | |
| SCHEMBL3970468 | 0.77 | ALDH1A1 (0.79) | RXFP1PRNPPPARGNR2E3NCOR2 | |
| SCHEMBL13881528 | 0.77 | ALDH1A1 (0.60) | RXFP1PRNPPPARGNR2E3NCOR2 | |
| SCHEMBL3961795 | 0.77 | RXFP1 (0.49) | RXFP1PRNPPPARGNR2E3NCOR2 | |
| SCHEMBL13881529 | 0.76 | RXFP1 (0.48) | RXFP1PRNPPPARGNR2E3NCOR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009041904-A1 | QUINOLINE COMPOUNDS HAVING AN ACTIVITY AGAINST THE GABAB RECEPTOR | ASTRAZENECA AB (SE) | 2009-04-02 | — | — | WO | disclosed |