Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 1/20 | 0.42 |
| ▸ | TDO2 | P48775 | 1/20 | 0.42 |
| ▸ | IDO2 | Q6ZQW0 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 7/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | DPP4 | P27487 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.38 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.37 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.37 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.37 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | ELOVL1 | Q9BW60 | 1/20 | 0.36 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.36 |
| ▸ | IKBKB | O14920 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3961778 | 0.92 | IDO1 (0.44) | IDO1TDO2IDO2MAPTTP53 | |
| SCHEMBL3970478 | 0.91 | KDM4E (0.47) | IDO1TDO2IDO2MAPTTP53 | |
| SCHEMBL3964828 | 0.85 | KCNH2 (0.43) | IDO1TDO2IDO2MAPTTP53 | |
| SCHEMBL3969490 | 0.84 | KCNH2 (0.41) | MAPTKDM4ELMNAALDH1A1HPGD | |
| SCHEMBL3963734 | 0.83 | DRD2 (0.45) | IDO1TDO2IDO2TP53KDM4E | |
| SCHEMBL3970359 | 0.82 | ELOVL1 (0.46) | IDO1TDO2IDO2MAPTKDM4E | |
| SCHEMBL3963960 | 0.82 | MCHR1 (0.42) | IDO1TDO2IDO2MAPTKDM4E | |
| SCHEMBL3966727 | 0.81 | PIK3CD (0.40) | IDO1TDO2IDO2TP53KDM4E | |
| SCHEMBL3965874 | 0.81 | FABP3 (0.49) | IDO1TDO2IDO2MAPTTP53 | |
| SCHEMBL3970453 | 0.81 | L3MBTL1 (0.38) | IDO1TDO2IDO2MAPTDPP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009041904-A1 | QUINOLINE COMPOUNDS HAVING AN ACTIVITY AGAINST THE GABAB RECEPTOR | ASTRAZENECA AB (SE) | 2009-04-02 | — | — | WO | disclosed |