Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | TRPM8 | Q7Z2W7 | 13/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | TSPO | P30536 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3963030 | 0.88 | TRPM8 (0.64) | TRPM8NPC1RAB9A | |
| SCHEMBL3959704 | 0.82 | TRPM8 (0.51) | TRPM8NPC1RAB9A | |
| SCHEMBL3963575 | 0.82 | TRPM8 (0.58) | TRPM8NPC1RAB9A | |
| SCHEMBL3963642 | 0.82 | TRPM8 (0.53) | TP53MAPTTRPM8NPC1RAB9A | |
| SCHEMBL3964680 | 0.81 | TRPM8 (0.52) | TP53MAPTTRPM8NPC1RAB9A | |
| SCHEMBL3956940 | 0.81 | MAPT (0.43) | TP53MAPTTRPM8 | |
| SCHEMBL3993748 | 0.79 | TP53 (0.55) | TP53MAPTTRPM8NPC1RAB9A | |
| SCHEMBL3963241 | 0.79 | PPARA (0.46) | TP53MAPTTRPM8 | |
| SCHEMBL3964923 | 0.79 | PPARA (0.46) | TP53MAPTTRPM8 | |
| SCHEMBL3965294 | 0.79 | PPARA (0.46) | TP53MAPTTRPM8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7488844-B2 | Therapeutic agents | ASTRAZENECA AB (SE) | 2009-02-10 | — | — | US | disclosed |
| US-20050282822-A1 | Therapeutic agents | ASTRAZENECA AB (SE) | 2005-12-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050282822-A1 | Therapeutic agents | GPR119, LIPC, PNLIP | TP53 4725/4885MAPT 4345/4885TRPM8 4071/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.