Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.46 |
| ▸ | CSF1R | P07333 | 1/20 | 0.43 |
| ▸ | S1PR1 | P21453 | 4/20 | 0.42 |
| ▸ | JAK3 | P52333 | 2/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.40 |
| ▸ | CLK4 | Q9HAZ1 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | TBK1 | Q9UHD2 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2585523 | 0.75 | TBK1 (0.46) | S1PR1CYP1A2CLK4ALDH1A1HSD17B10 | |
| SCHEMBL27858324 | 0.74 | JAK3 (0.41) | IRAK4S1PR1JAK3CYP1A2CLK4 | |
| SCHEMBL3963492 | 0.73 | KDM4E (0.47) | ALDH1A1KDM4EHPGD | |
| SCHEMBL3962368 | 0.72 | GPR39 (0.51) | CSF1RS1PR1CYP1A2CLK4ALDH1A1 | |
| SCHEMBL3034977 | 0.72 | S1PR1 (0.62) | S1PR1JAK3 | |
| SCHEMBL27997808 | 0.68 | KDM4E (0.69) | ALDH1A1KDM4EHPGDALOX15 | |
| SCHEMBL29598250 | 0.68 | MAPK1 (0.61) | ALDH1A1KDM4ETP53 | |
| SCHEMBL25388764 | 0.68 | S1PR1 (0.46) | S1PR1JAK3JAK2 | |
| SCHEMBL6299308 | 0.67 | ALDH1A1 (0.53) | CLK4ALDH1A1CYP2C9CYP3A4KDM4E | |
| SCHEMBL16401176 | 0.66 | ABL1 (0.55) | ALDH1A1HSD17B10KDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009034390-A1 | HETEROCYCLIC DERIVATIVES AND THEIR USE IN TREATING HEPATITIS C | ARROW THERAPEUTICS LIMITED (GB) | 2009-03-19 | — | — | WO | disclosed |