SCHEMBL3962914

SCHEMBL3962914

O=C(O)Cc1cccc([N+](=O)[O-])c1Cl

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 2/20 0.51
NPC1 O15118 3/20 0.48
RAB9A P51151 3/20 0.48
SMN1; SMN2 Q16637 2/20 0.48
CYP3A4 P08684 1/20 0.48
CYP2D6 P10635 1/20 0.48
CYP2C19 P33261 1/20 0.48
TSHR P16473 3/20 0.47
ALDH1A1 P00352 2/20 0.47
TDP1 Q9NUW8 3/20 0.46
AKR1B1 P15121 2/20 0.46
LMNA P02545 1/20 0.46
GPR35 Q9HC97 1/20 0.44
L3MBTL1 Q9Y468 2/20 0.43
AKR1B10 O60218 1/20 0.42
UGT1A9 O60656 1/20 0.42
TRPA1 O75762 1/20 0.42
ABCB11 O95342 1/20 0.42
MT-CO2 P00403 1/20 0.42
TTR P02766 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9780752 0.87 NPC1 (0.48) NPC1RAB9ASMN1; SMN2CYP3A4CYP2D6
SCHEMBL10939157 0.84 GRIA2 (0.50) CYP1A2NPC1RAB9ASMN1; SMN2CYP3A4
SCHEMBL74692 0.82 CYP1A2 (0.62) CYP1A2NPC1RAB9ASMN1; SMN2CYP3A4
SCHEMBL3953258 0.81 GPR35 (0.60) CYP1A2TSHRALDH1A1TDP1AKR1B1
SCHEMBL4388496 0.81 GPR35 (0.53) CYP1A2NPC1RAB9ASMN1; SMN2CYP3A4
SCHEMBL27861233 0.81 CYP1A2 (0.60) CYP1A2NPC1RAB9ASMN1; SMN2CYP3A4
SCHEMBL28157714 0.81 CYP1A2 (0.60) CYP1A2NPC1RAB9ASMN1; SMN2CYP3A4
SCHEMBL1067704 0.81 ALDH1A1 (0.56) NPC1RAB9ASMN1; SMN2CYP3A4CYP2D6
Hydrochloric Acid SCHEMBL2530464 0.81 CYP1A2 (0.60) CYP1A2NPC1RAB9ASMN1; SMN2CYP3A4
SCHEMBL28223983 0.81 CYP1A2 (0.60) CYP1A2NPC1RAB9ASMN1; SMN2CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2079486-A2 EFFICIENT SYNTHESIS OF CHELATORS FOR NUCLEAR IMAGING AND RADIOTHERAPY: COMPOSITIONS AND APPLICATIONS The Board of Regents of The University of Texas System (US) 2009-07-22 EP disclosed
WO-2008045604-A2 EFFICIENT SYNTHESIS OF CHELATORS FOR NUCLEAR IMAGING AND RADIOTHERAPY: COMPOSITIONS AND APPLICATIONS THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) 2008-04-17 WO disclosed
US-4502996-A Nucleophilic substitution process ETHYL CORPORATION (US) 1985-03-05 US disclosed