Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.48 |
| ▸ | RAB9A | P51151 | 4/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3962914 | 0.87 | CYP1A2 (0.51) | NPC1RAB9ASMN1; SMN2CYP2C19CYP3A4 | |
| SCHEMBL730581 | 0.84 | ALDH1A1 (0.61) | NPC1RAB9ASMN1; SMN2CYP2C19CYP3A4 | |
| SCHEMBL20971657 | 0.83 | GPR35 (0.51) | NPC1RAB9ASMN1; SMN2CYP2C19CYP3A4 | |
| SCHEMBL5506551 | 0.82 | TDP1 (0.56) | NPC1RAB9ASMN1; SMN2CYP2C19CYP3A4 | |
| SCHEMBL1067704 | 0.81 | ALDH1A1 (0.56) | NPC1RAB9ASMN1; SMN2CYP2C19CYP3A4 | |
| SCHEMBL11693636 | 0.79 | ALDH1A1 (0.69) | NPC1RAB9ASMN1; SMN2CYP2C19CYP3A4 | |
| SCHEMBL11189712 | 0.79 | ALDH1A1 (0.53) | NPC1RAB9ASMN1; SMN2CYP2C19CYP3A4 | |
| SCHEMBL14907881 | 0.79 | ALDH1A1 (0.53) | NPC1RAB9ASMN1; SMN2CYP2C19CYP3A4 | |
| SCHEMBL9806501 | 0.78 | CACNA1C (0.44) | NPC1RAB9ASMN1; SMN2CYP2C19CYP3A4 | |
| SCHEMBL28663049 | 0.78 | ALDH1A1 (0.53) | NPC1RAB9ASMN1; SMN2CYP2C19CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1020106-C | Process for pyrimidine derivatives | HOFFMANN LA ROCHE (CH) | 1993-03-17 | — | — | CN | disclosed |
| EP-0257378-B1 | PYRIMIDINE DERIVATIVES, THEIR PREPARATION AND MEDICAMENTS CONTAINING THESE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 1991-07-03 | — | — | EP | disclosed |
| US-5010060-A | Method of treating herpes simplex viral infection employing pyrimidine derivatives | HOFFMANN-LA ROCHE INC. (US) | 1991-04-23 | — | — | US | disclosed |
| US-4851519-A | AMIDO NUCLEOSIDES, VIRICIDES | HOFFMANN-LA ROCHE INC. (US) | 1989-07-25 | — | — | US | disclosed |
| EP-0257378-A1 | Pyrimidine derivatives, their preparation and medicaments containing these derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1988-03-02 | — | — | EP | disclosed |
| CN-87105758-A | Pyrimidine derivatives, their production and use | — | 1988-03-02 | — | — | CN | disclosed |