Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS1 | P29475 | 11/20 | 1.00 |
| ▸ | NOS3 | P29474 | 5/20 | 0.79 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.42 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3963410 | 1.00 | NOS1 (1.00) | NOS1NOS3NPY5RHRH4HRH3 | |
| Hydrochloric Acid SCHEMBL6249018 | 0.99 | NOS1 (0.98) | NOS1NOS3NPY5RHRH4HRH3 | |
| Hydrochloric Acid SCHEMBL6483053 | 0.98 | NOS1 (0.95) | NOS1NOS3NPY5RHRH4HRH3 | |
| Hydrochloric Acid SCHEMBL6253716 | 0.87 | NOS1 (0.78) | NOS1NOS3HSD17B10ADORA2AMAPT | |
| Hydrochloric Acid SCHEMBL6249898 | 0.87 | NOS1 (0.98) | NOS1NOS3NPY5RHRH4LMNA | |
| Hydrochloric Acid SCHEMBL6495633 | 0.86 | NOS1 (0.76) | NOS1NOS3LMNAADORA2AMAPT | |
| Hydrochloric Acid SCHEMBL6483905 | 0.86 | NOS1 (0.96) | NOS1NOS3HRH4LMNAHSD17B10 | |
| Hydrochloric Acid SCHEMBL6486035 | 0.84 | NOS1 (0.96) | NOS1NOS3HRH4MAPTL3MBTL1 | |
| SCHEMBL4323780 | 0.79 | NOS1 (1.00) | NOS1NOS3 | |
| SCHEMBL6253300 | 0.75 | NOS1 (0.81) | NOS1NOS3HTTMAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7541360-B2 | 4-amino-7,8-dihydropteridines, pharmaceutical compositions containing them and their use for the treatment of diseases which are caused by an increased nitric oxide level | VASOPHARM GMBH (DE) | 2009-06-02 | — | — | US | disclosed |
| US-20080027062-A1 | 4-Amino-7,8-Dihydropteridines, Pharmaceutical Compositions Containing Them and Their Use For The Treatment Of Diseases Which Are Caused By An Increased Nitric Oxide Level | VASOPHARM GMBH (DE) | 2008-01-31 | — | — | US | disclosed |
| EP-1699793-A1 | 4-AMINO-7,8-DIHYDROPTERIDINES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE FOR THE TREATMENT OF DISEASES WHICH ARE CAUSED BY AN INCREASED NITRIC OXIDE LEVEL | Vasopharm Biotech GmbH (DE) | 2006-09-13 | — | — | EP | disclosed |
| WO-2005063752-A1 | 4-AMINO-7,8-DIHYDROPTERIDINES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE FOR THE TREATMENT OF DISEASES WHICH ARE CAUSED BY AN INCREASED NITRIC OXIDE LEVEL | VASOPHARM BIOTECH GMBH (DE) | 2005-07-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080027062-A1 | 4-Amino-7,8-Dihydropteridines, Pharmaceutical Compositions Containing Them and Their Use For The Treatment Of Diseases Which Are Caused By An Increased Nitric Oxide Level | QDPR, PTGIS, NOS2 | NOS1 5/4885NOS3 6/4885NPY5R 433/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.