Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 3/20 | 0.45 |
| ▸ | DRD3 | P35462 | 3/20 | 0.45 |
| ▸ | HTR1A | P08908 | 2/20 | 0.45 |
| ▸ | HTR2A | P28223 | 2/20 | 0.45 |
| ▸ | HRH1 | P35367 | 1/20 | 0.45 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.45 |
| ▸ | DRD1 | P21728 | 1/20 | 0.43 |
| ▸ | DRD5 | P21918 | 1/20 | 0.43 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | HTR2B | P41595 | 1/20 | 0.40 |
| ▸ | ELOVL1 | Q9BW60 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 2/20 | 0.38 |
| ▸ | IDO1 | P14902 | 1/20 | 0.38 |
| ▸ | TDO2 | P48775 | 1/20 | 0.38 |
| ▸ | IDO2 | Q6ZQW0 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3962208 | 0.92 | HTR2A (0.47) | DRD2DRD3HTR1AHTR2AHRH1 | |
| SCHEMBL3969490 | 0.92 | KCNH2 (0.41) | KCNH2HRH3KDM4EPIK3CA | |
| SCHEMBL3963746 | 0.92 | MCHR1 (0.42) | DRD2DRD3HTR1AHTR2AHRH1 | |
| SCHEMBL3964828 | 0.91 | KCNH2 (0.43) | KCNH2HRH3ELOVL1IDO1TDO2 | |
| SCHEMBL3966727 | 0.90 | PIK3CD (0.40) | HRH1KCNH2HRH3ELOVL1IDO1 | |
| SCHEMBL4198373 | 0.89 | KCNH2 (0.39) | MCHR1KCNH2HRH3ELOVL1TP53 | |
| SCHEMBL3970649 | 0.88 | KCNH2 (0.41) | KCNH2HRH3IDO1TDO2IDO2 | |
| SCHEMBL3963960 | 0.87 | MCHR1 (0.42) | HTR1AMCHR1KCNH2POLBELOVL1 | |
| SCHEMBL3962203 | 0.85 | ELOVL1 (0.39) | HRH1KCNH2HRH3ELOVL1IDO1 | |
| SCHEMBL3970363 | 0.85 | DHFR (0.38) | KCNH2HRH3ELOVL1IDO1TDO2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009041904-A1 | QUINOLINE COMPOUNDS HAVING AN ACTIVITY AGAINST THE GABAB RECEPTOR | ASTRAZENECA AB (SE) | 2009-04-02 | — | — | WO | claimed |
| WO-2009041904-A1 | QUINOLINE COMPOUNDS HAVING AN ACTIVITY AGAINST THE GABAB RECEPTOR | ASTRAZENECA AB (SE) | 2009-04-02 | — | — | WO | disclosed |